NONINVASIVE QUANTITATION OF BIOCHEM CHANGESPARKINSONS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 帕金森病患者黑质生化变化的非侵入性定量(与神经病学Paul Tuite博士合作，由Dana基金会支持)：该项目的目标是通过高场MRS测量帕金森病患者黑质的神经化学变化。黑质是主要受帕金森氏病影响的大脑区域，MRS在该区域检测到的神经化学变化可能作为生物标志物以及提高我们对疾病机制的理解。然而，由于黑质结构的小尺寸和含铁量，MRS是非常具有挑战性的。我们在4特斯拉扫描仪上的初步数据已经证明了量化患者和对照中的10种神经化学物质的可行性，以及一些神经化学物质在患者中的变化趋势。我们在这个项目中的目标是将光谱方法转移到我们的7特斯拉扫描仪上，以提高灵敏度，并能够更好地定位黑质。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Noninvasive Quantitation of Biochemical Changes in the Human Substantia Nigra in Parkinson's Disease (in collaboration with Dr. Paul Tuite, Neurology, supported by Dana Foundation): The goal in this project is to measure neurochemical alterations by high field MRS in the substantia nigra of patients with Parkinson's disease. Substantia nigra is the brain region primarily affected by Parkinson's disease and neurochemical alterations detected by MRS in this region may be utilized as biomarkers as well as improve our understanding of disease mechanisms. However, MRS of substantia nigra is very challenging due to the small size and iron content of the structure. Our preliminary data at a 4 Tesla scanner has demonstrated the feasibility of quantifying 10 neurochemicals in patients and controls and trends for some neurochemicals to change in patients. Our goal in this project was to move the spectroscopy methods to our 7 Tesla scanner in order to improve sensitivity and to be able to localize better in the substantia nigra.