ENERGY METABOLISM OF PANCREATIC ISLETS:OXYGENATIONANTIOXIDANTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 胰岛的能量代谢：氧合状态和抗氧化剂的影响(与Klearchos Papas博士合作，外科)：胰岛移植是一种非常有希望的治疗方法，可以恢复1型糖尿病患者亚群的正常血糖。在与糖尿病免疫和移植研究所的合作中，我们的目标是使用MRS评估移植前和移植后胰岛的生存能力。我们开始了这个项目，比较了猪胰岛培养和模型在存在和没有抗氧化剂的情况下，在常氧和缺氧/缺氧条件下的无氧和氧化碳水化合物代谢(如13C核磁共振测量)和能量状态(如31P核磁共振测量)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Energy Metabolism of Pancreatic Islets: Effects of Oxygenation Status and Antioxidants (in collaboration with Dr. Klearchos Papas, Surgery): Islet transplantation is a highly promising treatment method for restoring normoglycemia in a subpopulation of patients with Type 1 diabetes. In this collaboration with the Diabetes Institute for Immunology and Transplantation our goal is to assess the pre- and post-transplant viability of pancreatic islets using MRS. We started the project by comparing anaerobic and oxidative carbohydrate metabolism (as measured by 13C NMR) and energy status (as measured by 31P NMR) of porcine islet cultures and islet models under normoxia versus hypoxia/anoxia in the presence and absence of antioxidants.