PIG TO NON-HUMAN PRIMATE ISLET XENOGRAFTS

猪与非人类灵长类动物胰岛异种移植

• 批准号: 8362846
• 负责人: KLEARCHOS K PAPAS
• 金额: $ 0.76万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362846
• 关键词: Collaborations; Diabetes Mellitus; Family suidae; Funding; Goals; Grant; Human; Institutes; Insulin-Dependent Diabetes Mellitus; Islet Cell; Islets of Langerhans Transplantation; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Methods; NMR Spectroscopy; National Center for Research Resources; Principal Investigator; Program Research Project Grants; Readiness; Research; Research Infrastructure; Resources; Site; Source; Transplantation; Transplantation Immunology; United States National Institutes of Health; Vascularization; Xeno; cost; islet; islet xenograft; nonhuman primate; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The long-term objective of this funded research is to treat type I Diabetes and to prevent its devastating complications using islet-cell xeno transplantation. Through the three funded program project grants we are actively exploring the use of porcine islets as an alternative to human islets for transplantation to reverse diabetes in humans. In this collaboration between the CMRR and the Diabetes Institute for Immunology and Transplantation (DIIT) at U of MN, our goal is to 1) assess the readiness and/or suitability of the transplantation site by measuring the vascularization with ultra high field (UHF) MRI and 2) assess the pre- and post-transplant viability of islets using magnetic resonance spectroscopy methods.

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