PIG TO NON-HUMAN PRIMATE ISLET XENOGRAFTS

猪与非人类灵长类动物胰岛异种移植

• 批准号: 8170451
• 负责人: KLEARCHOS K PAPAS
• 金额: $ 0.64万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8170451
• 关键词: Collaborations; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Family suidae; Funding; Goals; Grant; Human; Institutes; Institution; Insulin-Dependent Diabetes Mellitus; Islet Cell; Islets of Langerhans Transplantation; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Methods; Program Research Project Grants; Readiness; Research; Research Personnel; Resources; Site; Source; Transplantation; Transplantation Immunology; United States National Institutes of Health; Vascularization; Xeno; islet; islet xenograft; nonhuman primate; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term objective of this funded research is to treat type I Diabetes and to prevent its devastating complications using islet-cell xeno transplantation. Through the three funded program project grants we are actively exploring the use of porcine islets as an alternative to human islets for transplantation to reverse diabetes in humans. In this collaboration between the CMRR and the Diabetes Institute for Immunology and Transplantation (DIIT) at U of MN, our goal is to 1) assess the readiness and/or suitability of the transplantation site by measuring the vascularization with ultra high field (UHF) MRI and 2) assess the pre- and post-transplant viability of islets using magnetic resonance spectroscopy methods.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项资助研究的长期目标是使用胰岛细胞异种移植治疗I型糖尿病并预防其破坏性并发症。通过三个资助项目的赠款，我们正在积极探索使用猪胰岛作为替代人类胰岛移植，以扭转人类糖尿病。在CMRR和MN U的糖尿病免疫学和移植研究所（DIIT）之间的合作中，我们的目标是1）通过超高场（UHF）MRI测量血管化来评估移植部位的准备和/或适合性，2）使用磁共振光谱法评估胰岛移植前后的活力。