PIG TO NON-HUMAN PRIMATE ISLET XENOGRAFTS

猪与非人类灵长类动物胰岛异种移植

• 批准号: 7954986
• 负责人: KLEARCHOS K PAPAS
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954986
• 关键词: Collaborations; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Family suidae; Funding; Goals; Grant; Human; Institutes; Institution; Insulin-Dependent Diabetes Mellitus; Islet Cell; Islets of Langerhans Transplantation; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Methods; Program Research Project Grants; Readiness; Research; Research Personnel; Resources; Site; Source; Spectrum Analysis; Transplantation; Transplantation Immunology; United States National Institutes of Health; Vascularization; Xeno; islet; islet xenograft; nonhuman primate; prevent

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term objective of this funded research is to treat type I Diabetes and to prevent its devastating complications using islet-cell xeno transplantation. Through the three funded program project grants we are actively exploring the use of porcine islets as an alternative to human islets for transplantation to reverse diabetes in humans. In this collaboration between the CMRR and the Diabetes Institute for Immunology and Transplantation (DIIT) at U of MN, our goal is to 1) assess the readiness and/or suitability of the transplantation site by measuring the vascularization with ultra high field (UHF) MRI and 2) assess the pre- and post-transplant viability of islets using magnetic resonance spectroscopy methods.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项资助研究的长期目标是治疗I型糖尿病，并利用胰岛细胞异种移植预防其破坏性并发症。通过三项资助项目的资助，我们正在积极探索使用猪胰岛作为人类胰岛移植的替代方案，以逆转人类的糖尿病。在CMRR和明尼苏达大学糖尿病免疫与移植研究所(DIIT)的合作中，我们的目标是1)通过超高场磁共振(UHF)测量移植部位的血管形成来评估移植部位的就绪性和/或适宜性，以及2)使用磁共振波谱方法评估移植前后胰岛的存活情况。