BRAIN ABNORMALITIES IN ADOLESCENT OBESITY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目前的研究建议使用多种MRI技术（结构，弥散张量，功能性MRI和灌注）和神经认知评估，以彻底表征与青少年体重过度增加相关的大脑影响和潜在的认知障碍。我们计划采用横断面设计，研究体重正常或肥胖的年轻人。 我们的受试者将从IDEA研究纵向队列研究中招募-使用三年数据收集期跟踪青年（基线时年龄为10-16岁）。具体研究目的和假设如下： 目标1：使用以下MRI技术确定更大的体重与大脑变化的相关性：1）结构成像; 2）扩散张量成像; 3）功能性MRI和4）灌注MRI。 目的2：描述身体质量对认知的影响。 考虑到青少年肥胖的流行率，以及缺乏明确的脑成像数据，这项研究被认为是及时和必要的。这项调查的结果有望为医学专业人员提供有关肥胖的大脑机制的信息-最终，预防和治疗青少年肥胖。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The current research proposes to use multiple MRI techniques (structural, diffusion tensor, functional MRI, and perfusion), and neurocognitive assessments, to thoroughly characterize the brain effects, and potential cognitive impairments, associated with excess weight gain in adolescents. We plan to do this using a cross sectional design, studying youths who are either normal-weight or obese. Our subjects will be recruited from the IDEA Study longitudinal cohort study - that follows youth (ages 10-16 at baseline) using three yearly data collection periods. The specific research aims and hypotheses are as follows: Aim 1: Determine how greater body mass is associated with brain changes using the following MRI techniques: 1) Structural Imaging; 2) Diffusion tensor imaging; 3) Functional MRI, and 4) Perfusion MRI. Aim 2: Characterize the effect of body mass on cognition. Considering the pandemic rate of youth obesity, and the lack of explicit brain imaging data available, this research is considered timely and necessary. Results of this investigation are expected to inform medical professionals about the brain mechanisms of obesity - ultimately, towards prevention and treatment of adolescent obesity.