High Performance Connectome Upgrade for Human 3T MR Scanner

人类 3T MR 扫描仪的高性能连接组升级

• 批准号: 8637600
• 负责人: KELVIN O. LIM
• 金额: $ 60万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8637600
• 关键词: Brain; Brain imaging; Development; Diffusion; Functional Magnetic Resonance Imaging; Funding; General Hospitals; Human; Image; Magnetic Resonance; Magnetic Resonance Imaging; Massachusetts; Methodology; Methods; Minnesota; Performance; Physiologic pulse; Research; Research Personnel; Resolution; Rest; Running; Sampling; Site; United States National Institutes of Health; Universities; Washington; Weight; base; image reconstruction; neuroimaging; peer; prisma; response; software development

DESCRIPTION (provided by applicant): The aim of this proposal is to support a high performance upgrade for a Siemens Tim Trio scanner. The upgrade will greatly enhance ongoing NIH funded imaging research at the University of Minnesota, allowing investigators to fully utilize the advanced neuroimaging capabilities that are currently unavailable on standard 3 Tesla scanners, and, in particular, exploit the recently introduced advanced methodologies developed by the Human Connectome Project (HCP) teams at the Center for Magnetic Resonance Research (CMRR) and at Massachusetts General Hospital (MGH). This upgrade will also enable CMRR to continue HCP type methodology development on the proposed platform and continue the support of numerous (currently over sixty and rapidly increasing) other sites throughout the world that rely on pulse sequence and image reconstruction software developed and distributed from CMRR using "customer to peer" transfer mechanism. The proposed upgrade is based on a new, recently announced, 3 Tesla scanner (the Prisma) by Siemens. Prisma was developed in response to the significant gains in neuroimaging demonstrated by the two HCP consortia the WU-Minn consortium led by Washington University and University of Minnesota (CMRR) and the MGH-UCLA consortium. The HCP developed methods running on the two special "Connectome" 3T scanners, has brought new and exciting capabilities critical for advancements in brain imaging, such as subsecond whole brain, high resolution resting state- and task-fMRI, and high resolution (~ 1mm isotropic) diffusion weighted MR imaging (dMRI) for tractography and for microstructure determination using extensive q-space sampling.

描述（由申请人提供）：本提案旨在支持Siemens Tim Trio扫描仪的高性能升级。此次升级将大大增强明尼苏达大学正在进行的NIH资助的成像研究，使研究人员能够充分利用目前标准3特斯拉扫描仪上无法使用的先进神经成像功能，特别是，利用最近由磁共振研究中心（CMRR）和马萨诸塞州总医院（MGH）。此次升级还将使CMRR能够继续在拟议平台上开发HCP类型的方法，并继续支持全球众多（目前超过60个，并且正在迅速增加）其他站点，这些站点依赖于使用“客户对同行”传输机制从CMRR开发和分发的脉冲序列和图像重建软件。拟议的升级是基于一个新的，最近宣布，3特斯拉扫描仪（棱镜）由西门子。Prisma的开发是为了响应两个HCP联盟（华盛顿大学和明尼苏达大学（CMRR）领导的WU-Minn联盟和MGH-UCLA联盟）在神经成像方面的重大进展。HCP开发的方法运行在两个特殊的“Connectome”3 T扫描仪上，带来了新的和令人兴奋的功能，对脑成像的进步至关重要，如亚秒全脑，高分辨率静息状态和任务功能磁共振成像，高分辨率（~ 1 mm各向同性）扩散加权磁共振成像（dMRI），用于纤维束成像和使用广泛的q空间采样的微结构确定。