HIPPOCAMPAL FORMATION IN PSYCHOPATHY: A RADIAL MAPPING MR-BASED STUDY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 背景。精神病的神经生物学仍然模糊不清。内侧颞叶病变被认为是神经系统功能障碍的一部分，表现为暴力和精神病行为。在之前的一项研究中，Laakso及其同事使用磁共振测量了海马体的局部体积，发现海马体前后轴上的区域体积沿着与受试者的精神病程度相关。观察到精神病评分与双侧大脑半球后半部分之间存在强负相关。 瞄准在活体内定位精神病患者海马结构的结构变化。 方法. 26名精神病患者（年龄：32 <$8岁）和25名对照组（35 <$11岁）被纳入本研究。使用修订的精神病检查表评估精神病。通过在35个冠状切片上手动追踪配准到共同立体定向空间后的海马本体和下托的轮廓来分离海马结构。将使用专门开发的算法评估组差异，该算法使用三维参数表面网格模型。 预期成果。我们预期，在精神病患者和对照组之间，海马结构内的区域差异应该存在，并且应该与先前通过体积测量获得的结果一致（Laakso et al，2001）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 'Background. Neurobiology of psychopathy remains obscure. Medial temporal lobe pathology has been suggested to be a part of the neural systems dysfunction which manifests as violent and psychopathic behavior. In a previous study, Laakso and colleagues measured regional hippocampal volumes using magnetic resonance and found that the regional volumes along the anteroposterior axis of the hippocampus were correlated with the subjects' degree of psychopathy. Strong negative correlations were observed between the psychopathy scores and the posterior half of the hippocampi bilaterally. Aim. To locate in vivo the structural changes within the hippocampal formation in subjects with psychopathy. Methods. Twenty-six men with psychopathy (age:32¿8) and 25 controls (35¿11) were included in this study. Psychoapthy were assessed using the Psychopathy Checklist-Revised. The hippocampal formation will be isolated by manually tracing on 35 coronal slices the outlines of the hippocampus proper and subiculum after registration to a common stereotactic space. Group differences will be assessed with algorithms developed ad hoc that make use of three-dimensional parametric surface mesh models. Expected results. We expect that regional differences within the hippocampal formation should exist between psychopathy and controls and should be in line with previous results obtained with volumetric measurements (Laakso et al, 2001).