MORPHOSTRUCTURAL CEREBRAL FEATURES ASSOCIATED TO BORDERLINE AND

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 “与交界性和双相情感障碍相关的脑形态结构特征” 背景：交界性人格障碍(BPD)十分普遍，在普通人群中的发病率高达1%-2%，在精神科环境中，这一发病率高达15%-20%。尽管在许多研究中已经探索了BPD的心理社会原因，但关于生物原因的数据相对较少。神经成像在BPD研究中的应用仅可追溯到几年前。BPD与大脑的杏仁核和边缘系统有关，这两个系统控制情绪，特别是愤怒、恐惧和冲动的自动反应。研究表明，患有BPD的人的海马体和杏仁体可能会小16%，并表明创伤经历可能会导致这些神经解剖学上的变化。此外，还描述了与双相情感障碍(BD)和BPD的一些临床相似之处，尽管结果往往是相互矛盾的，而且不是详尽的。 目的：利用先进的神经成像工具研究与BPD和BP相关的脑形态结构特征，并评估特定脑区/环路与临床特征之间是否存在关联。 材料和方法。我们在研究中包括25个BDP，19个BP和46个对照。诊断将根据DSM IV标准进行。患者接受临床和神经心理评估。所有患者均行MR扫描，扫描方案包括3D T1加权序列和PD/T2加权双回波序列。健康受试者是连续的正常志愿者，他们是在布雷西亚Poliamanza医院的神经放射科接受脑MR扫描的人中连续挑选出来的，这些人的原因与认知无关，如偏头痛、听觉或视觉症状、感觉异常，扫描结果为阴性，并参加了一项关于正常脑结构的研究。在性别、年龄和教育程度方面，对照组与患者匹配。由于CS和遗传因素对大脑的影响，皮质模式匹配将用于检测和可视化皮质变异性。与文献一致，我们将使用放射状标测来研究海马区。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. "Morphostructural cerebral features associated to borderline and bipolar disorders" Background: Borderline personality disorder (BPD) is prevalent, affecting as many as 1% to 2% of the general population, and this incidence rises as high as 15% to 20% in psychiatric settings. Although psychosocial causes of BPD have been explored in many studies, relatively little data exist regarding biological causes. Use of neuroimaging in the study of BPD dates back only a few years. BPD has been linked to the amygdala and limbic systems of the brain, the centres that control emotion and, particularly, rage, fear and impulsive automatic reactions. Studies have shown that the hippocampus and the amygdala may be as much as 16% smaller in people with BPD and have suggested that experiences of trauma may lead to these neuroanatomical changes. Furthermore, some clinical similarity with Bipolar disorder (BD) and BPD have been described although the results are often contradictory and not exhaustive. Aim: To study morphostructural cerebral features associated to BPD and BP using advanced neuroimaging tools and to assess whether an association between specific cerebral areas/circuits and clinical features exists. Material and methods. We included in the study 25 BDP, 19 BP and 46 controls. Diagnoses will be made according DSM IV criteria. Patients underwent clinical and neuropsychological assessment. All patients will underwent MR. The scan protocol included a 3D T1-weighted sequence and PD/T2-weighted dual echo sequence. Healthy subjects were consecutive normal volunteers picked among those undergoing brain MR scan at the Neuroradiology Unit of the "Poliambulanza" Hospital, Brescia for reasons unrelated to cognition, such as migraine and headache, auditory or visual symptoms, paresthesias, and whose scan was negative and enrolled in a study on normal brain structure . Controls were matched to patients with regard to sex, age and education. Cortical pattern matching will be used to detect and visualize cortical variability due to the effect of CS and genetic factors on the brain. In line with literature we will study hippocampus using radial mapping.