MORPHOSTRUCTURAL CEREBRAL FEATURES ASSOCIATED TO BORDERLINE AND

与边缘和相关的大脑形态结构特征

• 批准号: 8363468
• 负责人: ROBERTA ROSSI
• 金额: $ 0.51万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363468
• 关键词: Affect; Age; Amygdaloid structure; Area; Auditory; Back; Biological; Bipolar Disorder; Borderline Personality Disorder; Brain; Cerebrum; Clinical; Cognition; Data; Diagnosis; Diagnostic and Statistical Manual; Education; Emotions; Enrollment; Fright; Funding; General Population; Genetic; Grant; Hippocampus (Brain); Hospitals; Incidence; Lead; Limbic System; Link; Literature; Maps; Methods; Migraine; Modeling; National Center for Research Resources; Paresthesia; Patients; Pattern; Principal Investigator; Protocols documentation; Radial; Rage; Reaction; Research; Research Infrastructure; Resources; Scanning; Source; Structure; Symptoms; Trauma; United States National Institutes of Health; Visual; Weight; computational anatomy; cost; experience; neuroimaging; neuropsychological; psychosocial; sex; tool; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. "Morphostructural cerebral features associated to borderline and bipolar disorders" Background: Borderline personality disorder (BPD) is prevalent, affecting as many as 1% to 2% of the general population, and this incidence rises as high as 15% to 20% in psychiatric settings. Although psychosocial causes of BPD have been explored in many studies, relatively little data exist regarding biological causes. Use of neuroimaging in the study of BPD dates back only a few years. BPD has been linked to the amygdala and limbic systems of the brain, the centres that control emotion and, particularly, rage, fear and impulsive automatic reactions. Studies have shown that the hippocampus and the amygdala may be as much as 16% smaller in people with BPD and have suggested that experiences of trauma may lead to these neuroanatomical changes. Furthermore, some clinical similarity with Bipolar disorder (BD) and BPD have been described although the results are often contradictory and not exhaustive. Aim: To study morphostructural cerebral features associated to BPD and BP using advanced neuroimaging tools and to assess whether an association between specific cerebral areas/circuits and clinical features exists. Material and methods. We included in the study 25 BDP, 19 BP and 46 controls. Diagnoses will be made according DSM IV criteria. Patients underwent clinical and neuropsychological assessment. All patients will underwent MR. The scan protocol included a 3D T1-weighted sequence and PD/T2-weighted dual echo sequence. Healthy subjects were consecutive normal volunteers picked among those undergoing brain MR scan at the Neuroradiology Unit of the "Poliambulanza" Hospital, Brescia for reasons unrelated to cognition, such as migraine and headache, auditory or visual symptoms, paresthesias, and whose scan was negative and enrolled in a study on normal brain structure . Controls were matched to patients with regard to sex, age and education. Cortical pattern matching will be used to detect and visualize cortical variability due to the effect of CS and genetic factors on the brain. In line with literature we will study hippocampus using radial mapping.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 子项目的主要研究者可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 “与边缘型和双相情感障碍相关的脑形态结构特征” 背景资料：边缘型人格障碍（BPD）很普遍，影响到1%到2%的普通人群，在精神科环境中，这种发病率高达15%到20%。虽然BPD的心理社会原因已经在许多研究中进行了探索，但关于生物原因的数据相对较少。神经影像学在BPD研究中的应用可以追溯到几年前。BPD与大脑的杏仁核和边缘系统有关，这些中心控制情绪，特别是愤怒，恐惧和冲动的自动反应。研究表明，BPD患者的海马体和杏仁核可能小16%，并表明创伤经历可能导致这些神经解剖学变化。此外，双相情感障碍（BD）和BPD的一些临床相似性已经被描述，尽管结果往往是矛盾的，并不详尽。 目的：使用先进的神经影像学工具研究与BPD和BP相关的形态结构脑特征，并评估特定脑区/回路与临床特征之间是否存在相关性。 材料和方法。我们在研究中包括25个BDP，19个BP和46个对照。诊断将根据DSM IV标准进行。患者接受了临床和神经心理学评估。所有患者将接受MR检查。扫描方案包括3D T1加权序列和PD/T2加权双回波序列。健康受试者是连续的正常志愿者，他们是从布雷西亚“Poliambulanza”医院神经放射科因与认知无关的原因（如偏头痛和头痛、听觉或视觉症状、感觉异常）接受脑MR扫描的志愿者中挑选出来的，他们的扫描结果为阴性，并参加了一项关于正常脑结构的研究。对照组在性别、年龄和教育程度方面与患者相匹配。皮质模式匹配将用于检测和可视化由于CS和遗传因素对大脑的影响而导致的皮质变异性。根据文献，我们将使用放射状映射研究海马。