HIPPOCAMPAL FORMATION IN PSYCHOPATHY: A RADIAL MAPPING MR-BASED STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 “背景。精神病的神经生物学仍不清楚。内侧颞叶病变被认为是神经系统功能障碍的一部分，表现为暴力和精神病行为。在之前的一项研究中，Laakso和他的同事利用磁共振测量了海马区的体积，发现海马体前后轴的区域体积与受试者的精神病程度相关。”精神变态评分与双侧海马区后半部呈显著负相关。 瞄准。目的：在活体内定位精神病患者海马区结构的变化。 方法：研究方法。26名男性精神病患者(年龄：32±8岁)和25名对照组(年龄：35±11岁)被纳入本研究。用修订后的《精神变态检查表》评估精神淡漠。在注册到一个共同的立体定向空间后，将通过在35个冠状切片上手动跟踪海马体和下丘脑的轮廓来分离海马体结构。群体差异将通过使用三维参数曲面网格模型的特别开发的算法进行评估。 预期结果。我们预计，在精神病患者和对照组之间，海马区结构的区域差异应该存在，并且应该与先前通过体积测量获得的结果一致(Laakso等人，2001)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 'Background. Neurobiology of psychopathy remains obscure. Medial temporal lobe pathology has been suggested to be a part of the neural systems dysfunction which manifests as violent and psychopathic behavior. In a previous study, Laakso and colleagues measured regional hippocampal volumes using magnetic resonance and found that the regional volumes along the anteroposterior axis of the hippocampus were correlated with the subjects' degree of psychopathy. Strong negative correlations were observed between the psychopathy scores and the posterior half of the hippocampi bilaterally. Aim. To locate in vivo the structural changes within the hippocampal formation in subjects with psychopathy. Methods. Twenty-six men with psychopathy (age:32¿8) and 25 controls (35¿11) were included in this study. Psychoapthy were assessed using the Psychopathy Checklist-Revised. The hippocampal formation will be isolated by manually tracing on 35 coronal slices the outlines of the hippocampus proper and subiculum after registration to a common stereotactic space. Group differences will be assessed with algorithms developed ad hoc that make use of three-dimensional parametric surface mesh models. Expected results. We expect that regional differences within the hippocampal formation should exist between psychopathy and controls and should be in line with previous results obtained with volumetric measurements (Laakso et al, 2001).