CEREBRAL ASYMMETRY AND LANGUAGE IN AUTISM

自闭症患者的大脑不对称和语言

• 批准号: 7955777
• 负责人: DONALD C. ROJAS
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955777
• 关键词: Adult; Affect; Age; Area; Auditory; Autistic Disorder; Brain region; Cerebrum; Child; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Family history of; Family member; Funding; Goals; Grant; Individual; Institution; Laboratories; Language; Language Delays; Language Development; Left; Magnetic Resonance Imaging; Measures; Modeling; Parents; Process; Recording of previous events; Research; Research Personnel; Resources; Risk Factors; Source; Surface; United States National Institutes of Health; computational anatomy; developmental disease; endophenotype; language processing; phonology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main goal of this proposal is to evaluate whether left hemisphere planum temporale (PT) volume reduction, assessed by morphometric analysis of magnetic resonance imaging (MRI) data, is present in the parents of children with autism. Such a finding would bolster support our hypothesis that PT volume reduction represents a familial risk factor for language delay and deviance often seen in individuals with autistic disorder. Preliminary evidence from our laboratory suggests that alteration in the volume of the planum temporale in both adults and children with autism. The planum temporale (PT) is an auditory processing brain region intimately associated with language processing in the left hemisphere in normal development. Measuring the PT in non-affected family members will allow us to assess whether the PT alteration in autism is familial, the next logical step in determining if PT volume change will be a productive endophenotype. We are proposing to measure PT volume and surface area in 20 parents of children with autism, 20 age-matched adults with autism and 20 adults with no personal or familial history of autism or other developmental disorders. We hypothesize that the volume of the left PT will be significantly smaller in the parent group compared to the controls, and that the PT volume in the adult autism group will be lower than that for the parent group (consistent with the view that not all of the parents in the autism group will carry the risk factor in question). We will also measure language function and assess the family history of language development in the same three groups of adults. Measures of receptive and expressive language, as well as phonology and pragmatics, will be obtained in all of the adults and correlated to the MRI findings.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该提案的主要目标是评估自闭症儿童的父母是否存在左半球颞平面（PT）体积减少（通过磁共振成像（MRI）数据的形态测量分析来评估）。 这一发现将支持我们的假设，即 PT 量减少是自闭症患者中常见的语言迟缓和异常的家族风险因素。 我们实验室的初步证据表明，成人和自闭症儿童的颞平面体积均发生变化。 颞平面 (PT) 是一个听觉处理大脑区域，与正常发育中左半球的语言处理密切相关。 测量未受影响的家庭成员的 PT 将使我们能够评估自闭症的 PT 改变是否具有家族性，这是确定 PT 体积变化是否是一种有效的内表型的下一个逻辑步骤。 我们建议测量 20 名自闭症儿童的父母、20 名年龄匹配的自闭症成人和 20 名没有自闭症或其他发育障碍个人或家族史的成人的 PT 体积和表面积。 我们假设，与对照组相比，父母组的左侧 PT 体积将显着较小，并且成人自闭症组的 PT 体积将低于父母组（与自闭症组中并非所有父母都会携带相关危险因素的观点一致）。 我们还将测量这三组成年人的语言功能并评估语言发展的家族史。 将对所有成年人进行接受性和表达性语言以及音韵学和语用学的测量，并将其与 MRI 结果相关联。