Sensorimotor abnormalities in childhood onset psychotic disorders

儿童期发病的精神障碍中的感觉运动异常

• 批准号: 7845501
• 负责人: DONALD C. ROJAS
• 金额: $ 34.54万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7845501
• 关键词: Adolescent; Age; Area; Attention; Basal Ganglia; Behavior; Behavioral; Biological Markers; Bipolar Disorder; Brain; Brain region; Categories; Cerebellum; Child; Childhood; Clinical; Control Groups; Development; Diagnosis; Disease; Exhibits; Failure; Family; Family Study; Family history of; Feedback; Fingers; Frequencies; Future; Gender; Genetic; Genetic Risk; Goals; Ipsilateral; Knowledge; Lead; Life; Magnetic Resonance Imaging; Magnetoencephalography; Measures; Methods; Metric; Mood Disorders; Moods; Motor; Motor Cortex; Movement; Neurobiology; Neurologic; Neuronal Dysfunction; Onset of illness; Participant; Patients; Performance; Phase; Psychotic Disorders; Public Health; Research; Risk Factors; Schizophrenia; Severities; Signal Transduction; Somatosensory Cortex; Structure; Structure-Activity Relationship; Symptoms; Techniques; Testing; Time; base; caudate nucleus; early childhood; feeding; improved; motor deficit; neurobehavioral; neuroimaging; neurophysiology; outcome forecast; patient population; public health relevance; research study; response; somatosensory; theories; treatment planning

DESCRIPTION (provided by applicant): We are requesting support for a study of brain sensorimotor abnormalities in childhood onset psychotic illnesses. Motor deficits are consistently found in psychotic patient populations and have also been identified as among a few promising early childhood risk factors for psychosis. We will employ a combination of neurobehavioral methods with non-invasive neuroimaging using magnetoencephalography (MEG) and structural magnetic resonance imaging (MRI). Eighty young participants with either childhood onset psychotic bipolar disorder (N=40) or schizophrenia (N=40) will be compared to age and gender matched comparison subjects (N=40) without personal or family history of psychotic and/or bipolar mood disorders. Our general perspective on motor coordination deficits is two-fold. First, we propose that a failure in inter-hemispheric motor inhibition results in failures to properly coordinate timing signals in bimanual coordination. Second, we believe that a failure in feed-forward efferent copy mechanisms from motor to somatosensory cortex results in improper perceptual feedback during patient's own movements. Our long term goals for this research are to refine the neurobiology of motor deficits in psychotic disorders, develop biomarkers for future family-based studies of genetic risk and evaluate neurobiological differences between schizophreniform and mood-related psychotic illnesses. Some of these biomarkers should be associated with psychosis per se and others with more disorder specific clinical manifestations. Such knowledge could a) contribute to earlier and more accurate diagnosis, b) lead to improved treatment planning at onset of illness, c) assist with more accurate estimate of illness trajectory and prognosis, d) aid in the development of possible new endophenotypic markers for psychosis, and e) form the basis for future family studies relating to genetic vs. developmental contributions to these disorders. PUBLIC HEALTH RELEVANCE: Psychotic illnesses including schizophrenia and bipolar disorder with psychotic features are significant public health concerns. Although much focus has been given to specific risk factors for each illness, little attention has been paid to factors in common between the disorders (i.e., a dimensional approach rather than categorical approach to risk factors). Impaired motor behavior is a promising risk factor for psychoses broadly defined. Our long term goals for this research are to refine the neurobiology of motor deficits in psychotic disorders across category and develop biomarkers for future family-based studies of genetic risk. Some of these biomarkers should be associated with psychosis per se and others with more disorder specific clinical manifestations (e.g., specific to schizophrenia). Such knowledge could a) contribute to earlier and more accurate diagnosis, b) lead to improved treatment planning at onset of illness, c) assist with more accurate estimate of illness trajectory and prognosis, d) aid in the development of possible new endophenotypic markers for psychosis, and e) form the basis for future family studies relating to genetic vs. developmental contributions to these disorders.

描述（由申请人提供）：我们要求支持童年发作中脑感觉运动异常的研究。在精神病患者人群中始终发现运动缺陷，并且也被确定为精神病的一些有希望的早期幼儿危险因素。我们将采用磁脑电图（MEG）和结构磁共振成像（MRI）的神经行为方法与非侵入性神经影像的结合。具有童年发作性躁郁症（n = 40）或精神分裂症（n = 40）的八十名年轻参与者将与年龄和性别匹配的比较主体（n = 40）进行比较，而没有精神病和/或躁郁症情绪障碍的个人或家族史。我们对运动协调缺陷的一般看法是两个方面。首先，我们提出，半球间电动机抑制失败导致未能正确协调双层协调中的时序信号。其次，我们认为，从电动机到体感皮层的饲喂传出拷贝机制失败导致患者自身运动期间的感知反馈不当。这项研究的长期目标是完善精神病中运动缺陷的神经生物学，为将来的基于家庭的遗传风险研究开发生物标志物，并评估精神分裂症和与情绪有关的精神病性疾病之间的神经生物学差异。这些生物标志物中的一些应与精神病本身有关，而具有更具体的临床表现。这些知识可以a）a）有助于提前，更准确的诊断，b）导致疾病发作后改善治疗计划，c）有助于更准确地估算疾病轨迹和预后，d）帮助开发有关精神病的新末日型标记，以及e）构成了与基因vs.sticent vss for centic vss for consection vss for centic vss for centic vss for consects cons for centic vss for centic vss for consection vss for centic vss for consection vss consection v。公共卫生相关性：精神病疾病，包括精神分裂症和具有精神病特征的双相情感障碍是公共卫生的重大问题。尽管对每种疾病的特定危险因素都非常重点，但很少关注疾病之间的共同因素（即一种维度方法，而不是危险因素的分类方法）。运动行为受损是广泛定义的精神病的有希望的危险因素。这项研究的长期目标是完善类别跨类精神病的运动缺陷的神经生物学，并为将来的基于家庭的遗传风险研究开发生物标志物。其中一些生物标志物应与精神病本身有关，而具有更具体的临床表现（例如，特定于精神分裂症）。这些知识可以a）a）有助于提前，更准确的诊断，b）导致疾病发作后改善治疗计划，c）有助于更准确地估算疾病轨迹和预后，d）帮助开发有关精神病的新末日型标记，以及e）构成了与基因vs.sticent vss for centic vss for consection vss for centic vss for centic vss for consects cons for centic vss for centic vss for consection vss for centic vss for consection vss consection v。