Neural synchronydysfunction of gamma oscillations in autism

自闭症伽马振荡的神经同步功能障碍

• 批准号: 8372405
• 负责人: DONALD C. ROJAS
• 金额: $ 25.45万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8372405
• 关键词: Adult; Affect; Age; Animal Model; Attention; Auditory; Auditory area; Autistic Disorder; Binding; Biological; Brain; Candidate Disease Gene; Cerebral cortex; Child; Cognitive; Computer Simulation; Cortical Desynchronizations; Cortical Synchronization; Data; Development; Electroencephalography; Enrollment; Family; Family history of; Family member; First Degree Relative; Frequencies; Functional disorder; Future; GABA Receptor; Gender; Genetic; Goals; Head; Image; Individual; Intervention; Laboratories; Literature; Magnetic Resonance Imaging; Magnetoencephalography; Measurement; Measures; Methods; Neocortex; Neurons; Noise; Parents; Pattern; Performance; Persons; Phase; Phenotype; Play; Power Sources; Publishing; Recording of previous events; Role; Sampling; Signal Transduction; Source; Stimulus; System; Techniques; Thick; Time; Triad Acrylic Resin; autism spectrum disorder; central coherence; design; developmental disease; endophenotype; follow-up; gamma-Aminobutyric Acid; interest; magnetic field; neurobehavioral; proband; public health relevance; relating to nervous system; research study; selective attention; sensor; translational study

DESCRIPTION (provided by applicant): It has been proposed that general abnormalities in structural and functional neuronal connectivity may underlie many of the triad of deficits observed in autism. A limited number of deficits at the neuronal level, widely expressed in multiple neurobehavioral systems could provide substantial explanatory power in autism. For example, abnormal temporal binding and weak central coherence may be related to alterations in brain functional and/or structural connectivity. Gamma band oscillatory activity, as measured using EEG and magnetoencephalography (MEG), has been associated with intrinsic GABAergic activity in animal and computational models of the neocortex and is thought to play an important role in binding and central coherence. We and others have published data demonstrating that gamma activity is abnormal in people with autism, possibly reflecting a cortical GABA dysfunction. Using a whole-head MEG system, we will assess patterns of auditory cortical synchronization with high precision in both time and frequency. As we are primarily interested in the development of new endophenotypes for autism, we will study parents of affected individuals as well as probands. Preliminary evidence from our laboratory indicates that a gamma- synchronization deficit may be familial. Forty families who have children with autism will be enrolled and the parents of the children will be assessed using MEG measures of gamma-band activity in auditory experiments. Their data will be compared to matched adults with no personal or family history of autism spectrum disorders their children. MEG measures of gamma power and phase-locking will be measured and associated with their structural underpinnings from magnetic resonance imaging (MRI) data and also with measures of the broad autism phrenotype.

描述（由申请人提供）：已经提出，结构和功能神经元连接的一般异常可能是在自闭症中观察到的许多三联缺陷的基础。在神经元水平上，在多个神经行为系统中广泛表达的有限数量的缺陷可以为自闭症提供实质性的解释力。例如，异常的时间绑定和弱的中央一致性可能与大脑功能和/或结构连接的改变有关。使用EEG和脑磁图（MEG）测量的伽马带振荡活动与动物和新皮层计算模型中的固有GABA能活动相关，并被认为在结合和中枢相干性中发挥重要作用。我们和其他人发表的数据表明，伽马活动在自闭症患者中是异常的，可能反映了皮质GABA功能障碍。使用全头脑磁图系统，我们将评估模式的听觉皮层同步与高精度的时间和频率。由于我们主要对自闭症新的内在表型的发展感兴趣，我们将研究受影响个体的父母以及先证者。我们实验室的初步证据表明，γ同步缺陷可能是家族性的。将招募40个有自闭症儿童的家庭，并在听觉实验中使用MEG测量伽马波段活动来评估儿童的父母。他们的数据将与匹配的成年人进行比较，这些成年人没有自闭症谱系障碍的个人或家族史。将测量伽马功率和锁相的MEG测量值，并将其与来自磁共振成像（MRI）数据的结构基础以及广泛的自闭症phrenotype的测量值相关联。

项目成果

Abnormalities in gamma-band responses to language stimuli in first-degree relatives of children with autism spectrum disorder: an MEG study.

• DOI: 10.1186/1471-244x-12-213
• 发表时间: 2012-11-29
• 期刊: BMC psychiatry
• 影响因子: 4.4
• 作者: McFadden KL;Hepburn S;Winterrowd E;Schmidt GL;Rojas DC
• 通讯作者: Rojas DC

The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatment.

谷氨酸及其受体在自闭症中的作用以及谷氨酸受体拮抗剂在治疗中的应用。

• DOI: 10.1007/s00702-014-1216-0
• 发表时间: 2014-08
• 期刊: Journal of neural transmission (Vienna, Austria : 1996)
• 作者: Rojas DC

MEG and EEG demonstrate similar test-retest reliability of the 40Hz auditory steady-state response.

• DOI: 10.1016/j.ijpsycho.2017.01.013
• 发表时间: 2017-04
• 期刊: International journal of psychophysiology : official journal of the International Organization of Psychophysiology
• 作者: Legget KT;Hild AK;Steinmetz SE;Simon ST;Rojas DC
• 通讯作者: Rojas DC

Transient and steady-state auditory gamma-band responses in first-degree relatives of people with autism spectrum disorder.

• DOI: 10.1186/2040-2392-2-11
• 发表时间: 2011-07-05
• 期刊: Molecular autism
• 影响因子: 6.2
• 作者: Rojas DC;Teale PD;Maharajh K;Kronberg E;Youngpeter K;Wilson LB;Wallace A;Hepburn S
• 通讯作者: Hepburn S