CONNECTIONS OF THE LIMBIC SYSTEM AND HYPOTHALAMUS

边缘系统和下丘脑的连接

• 批准号: 7955797
• 负责人: LARRY W SWANSON
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955797
• 关键词: Aggressive behavior; Anorexia; Anxiety; Appetite Regulation; Back; Behavior; Blood Glucose; Brain; Brain Part; Brain Stem; Cardiovascular system; Cerebral hemisphere; Chemistry; Classification; Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Diffuse; Dorsal; Emotions; Endocrine; Food; Funding; Genes; Grant; Histocytochemistry; Hunger; Hypothalamic structure; Individual; Institution; Internet; Lateral; Limbic System; Measures; Medial; Mediating; Menstrual cycle; Methods; Modeling; Moods; Neuraxis; Neurons; Neurotransmitters; Obesity; Output; Pathology; Pathway interactions; Pattern; Phase; Physiology; Pituitary Gland; Rattus; Recording of previous events; Reproductive Behavior; Research; Research Personnel; Resolution; Resources; Sex Behavior; Sleep; Sleep Wake Cycle; Source; Spinal Cord; Structure; System; Thirst; United States National Institutes of Health; Wakefulness; Work; base; cell type; computational anatomy; design; fighting; neural circuit; neuroinformatics; reproductive

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term objective of the proposed work is to identify and characterize at high resolution the structure and chemistry of neural circuits in the mammalian brain that underlie the basic drives and emotions keeping individuals alive and assuring survival of the species associated with hunger and thirst, defensive (fight or flight) behavior, reproductive (sexual and parental) behavior, and the sleep/wake cycle. Previous work identified the hypothalamus as a critical node in this circuitry, and characterized in detail axonal input/output relationships of its medial half with the pituitary gland, cerebral hemispheres, and brainstem/spinal cord. The proposed work is designed to complete in a systematic way, and to extend, a similar analysis of the lateral hypothalamus, and is based on the hypothesis that the lateral hypothalamus consists of two fundamentally different components, a dorsal region with widespread, diffuse projections to much of the central nervous system, and a surrounding compartmentalized region divided into some two dozen parts with very specific projection patterns to specific functional systems. The three specific aims are, a) to complete a phase one, regional analysis of the surrounding compartmentalized region; b) to begin a phase two, neuronal cell type analysis, starting with certain lateral hypothalamic regions apparently involved critically in food appetite regulation; and c) to facilitate the entry of neuroanatomical data into neuroinformatics workbenches on the web. The research is based on the combined use in rats of experimental intra-axonal pathway tracing methods, and hybridization histochemistry for the cell type-specific expression of neurotransmitter-related genes. There is a rich clinical and experimental history, dating back over a century, that disturbances of the hypothalamus, and parts of the brain interacting with the hypothalamus, produce depending on localization either obesity or anorexia, profound effects on cardiovascular and endocrine (for example, blood glucose) measures, anxiety and mood, aggressive behavior, sexual behavior and physiology (for example, the menstrual cycle), and disturbances of normal sleep and wakefulness patterns. The proposed research is designed to clarify very poorly understood neural circuits that mediate normal ingestive, defensive, reproductive, and sleep/wake behaviors; understanding their pathology will follow.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 拟议工作的长期目标是在高分辨率上识别和表征哺乳动物大脑中神经回路的结构和化学，这是基本的驱动力和情感，使个人活着，并确保与饥饿和口渴，防御性（战斗或飞行）行为相关的物种的存活，生殖（性和养生（性和养生）行为以及睡眠/唤醒周期。先前的工作将下丘脑确定为该电路中的关键节点，并详细介绍了其内侧一半与垂体，脑半球和脑干/脊髓的轴突输入/输出关系。拟议的工作旨在以系统的方式完成，并扩展对下丘脑的类似分析，并基于以下假设：下丘脑外侧下丘脑由两个根本不同的组成部分组成，一个基本的组成部分，一个背侧区域，具有广泛的，分散的阶段，对周围的中心神经系统的广泛范围，以及对周围的划分划分的部分进行了两种划分的部分。三个特定的目的是：a）完成对周围隔室化区域的区域分析； b）开始第二阶段的神经元细胞类型分析，从某些侧面下丘脑区域开始显然参与食用食欲调节。 c）促进神经解剖学数据进入网络上的神经信息函数工作台。该研究基于实验性轴内途径追踪方法的大鼠的综合用途，以及与神经递质相关基因的细胞类型特异性表达的杂交组织化学。有一段悠久的临床和实验历史可以追溯到一个世纪以上，下丘脑的干扰以及大脑与下丘脑的部分相互作用，取决于肥胖或厌食症，对心血管疾病和内分泌（例如，血液葡萄糖）的焦虑和情绪，性行为，性行为，性行为和物理学的态度（例如，焦虑症）对心血管疾病和内分泌产生深远影响，例如清醒模式。拟议的研究旨在阐明介导正常摄入，防御性，生殖和睡眠/唤醒行为的神经回路非常了解的。了解他们的病理学将随之而来。