CONNECTIONS OF LIMBIC SYSTEM & HYPOTHALAMUS

边缘系统的连接

• 批准号: 7369371
• 负责人: LARRY W SWANSON
• 金额: $ 1.02万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369371
• 关键词: CONNECTIONS; LIMBIC; SYSTEM; HYPOTHALAMUS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothalamus and limbic system are widely thought to provide the neural substrates for motivation and emotion, although the organization of its connections, and indeed the definition of what structures should even be included within the limbic system, is poorly understood and controversial. The long range goal of our work on this topic, which is now in its twentieth year of funding, is to determine with neuroanatomical methods (combined pathway tracing and histochemistry for neurotransmission-related molecules) the precise topographical organization of pathways that interconnect the various nuclei of the hypothalamus, of pathways that innervate the hypothalamus from medial regions of the telencephalon (such as the amygdala and hippocampus), and of pathways that descend from the hypothalamus to brainstem and spinal cord to initiate various classes of instinctive, goal-oriented behavior (e.g., ingestive, reproductive, and defensive).

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。人们普遍认为，下丘脑和边缘系统为动机和情绪提供了神经基础，尽管它的联系的组织，甚至边缘系统中应该包括什么结构的定义，人们还知之甚少，也存在争议。我们在这个课题上的工作的长期目标是用神经解剖学方法(神经传递相关分子的联合路径追踪和组织化学)确定相互连接下丘脑不同核的路径的精确地形组织，从端脑的内侧区域(如杏仁核和海马体)支配下丘脑的路径，以及从下丘脑下行到脑干和脊髓的路径，以启动各种类型的本能、目标导向行为(如摄食、生殖和防御)。