A MATURE BRAIN ARCHITECTURE KNOWLEDGE MANAGEMENT SYSTEM

成熟的大脑架构知识管理系统

• 批准号: 7955660
• 负责人: LARRY W SWANSON
• 金额: $ 1.36万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955660
• 关键词: Affect; Alzheimer' s Disease; Animal Model; Architecture; Biological; Brain; Brain Chemistry; Chemicals; Complement; Computer Retrieval of Information on Scientific Projects Database; Development; Disease model; Emotions; Epilepsy; Foundations; Funding; Goals; Grant; Health; Information Resources Management; Institution; Learning; Limbic System; Memory; Modeling; Multiple Sclerosis; Narcolepsy; Neurons; Neurosciences; Neurosciences Research; Online Systems; Parkinson Disease; Rattus; Research; Research Personnel; Resources; Source; Staging; Stroke; Structure; System; United States National Institutes of Health; cell type; chronic pain; computational anatomy; gray matter; nervous system disorder; neuroinformatics; public health relevance; web site; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goal of the proposed research is to create a fully functional online workbench for obtaining information about the biological circuits that make up the brain, and for modeling the functional organization of this circuitry in health and in a broad range of neurological diseases, including Alzheimer's, chronic pain, epilepsy, multiple sclerosis, Parkinson's, stroke, and narcolepsy. One strength of this approach in early stages of development is that it complements experimental systems neuroscience research in the lab on the fundamental structural and chemical organization of limbic system circuits that control the basic drives and emotions, along with learning and memory. The foundation of the neuroinformatics research proposed here is a functioning, relatively heavily used website begun in 2001 and called the Brain Architecture Knowledge Management System (Google: BAMS). It is currently the only online system that integrates neuroscience information at four levels of organization: gray matter Regions, neuronal Cell Types making up regions, white matter axonal Connections between regions and cell types, and expressed Molecules. PUBLIC HEALTH RELEVANCE: All of the major neurological diseases are studied in animal models including rat. The goal of the proposed research is to create a widely used online website for accessing information about the structure and chemistry of brain circuits and systems involved in health and disease, and for modeling the basic wiring diagram of the brain and how it is affected in specific neurological diseases, treated in specific ways.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 拟议研究的长期目标是创建一个功能齐全的在线工作台，用于获取有关构成大脑的生物回路的信息，并对健康和广泛的神经系统疾病（包括阿尔茨海默氏症，慢性疼痛，癫痫，多发性硬化症，帕金森氏症，中风和嗜睡症）中该回路的功能组织进行建模。这种方法在早期发展阶段的一个优势是，它补充了实验室中关于边缘系统电路的基本结构和化学组织的实验系统神经科学研究，这些电路控制基本的驱动力和情绪，沿着学习和记忆。这里提出的神经信息学研究的基础是一个功能强大、使用相对频繁的网站，该网站始于2001年，名为大脑结构知识管理系统（Google：BAMS）。它是目前唯一一个在四个组织层次上整合神经科学信息的在线系统：灰质区域，构成区域的神经元细胞类型，区域和细胞类型之间的白色物质轴突连接，以及表达分子。公共卫生相关性：所有主要的神经系统疾病都是在包括大鼠在内的动物模型中进行研究的。拟议研究的目标是创建一个广泛使用的在线网站，用于访问有关健康和疾病所涉及的大脑回路和系统的结构和化学信息，并对大脑的基本布线图进行建模，以及它如何在特定的神经系统疾病中受到影响，以特定的方式治疗。