STRUCTURAL STUDIES OF CELL ADHESION PROTEINS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们的工作主要集中在钙粘附素细胞黏附分子上。在人类基因组中发现了大约100种钙粘附素。它们表达在固体组织的所有细胞表面，它们之间的结合将细胞结合在一起形成多细胞结构，如组织层。钙粘附素的差异结合在动物多细胞结构的发育中起着重要作用，但对其选择性却知之甚少。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our work focuses mainly on cadherin cell adhesion molecules. About 100 cadherins are found in the human genome. They are expressed on the surfaces of all cells of solid tissues, and binding between them holds cells together in multicellular structures such as tissue layers. The differential binding of cadherins plays an important role in the development of the multicellular structures of animals, yet their selectivity is little understood.