STRUCTURAL STUDIES OF RHODOPSIN

视紫质的结构研究

• 批准号: 7955195
• 负责人: Ronald E Stenkamp
• 金额: $ 0.22万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955195
• 关键词: Affect; Complex; Computer Retrieval of Information on Scientific Projects Database; Development; Drug Delivery Systems; Family; Funding; G-Protein-Coupled Receptors; GTP-Binding Proteins; Goals; Grant; Institution; Investigation; Membrane; Modeling; Molecular; Nature; Pharmacologic Substance; Photons; Photoreceptors; Process; Proteins; Research; Research Personnel; Resources; Retina; Rhodopsin; Signal Transduction; Source; Structure; System; Therapeutic Agents; Transducin; United States National Institutes of Health; Vision; absorption; base; computerized data processing; receptor; structural biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this project are to obtain crystal structural determinations for rhodopsin and its complexes with other proteins. Rhodopsin is the G-protein coupled receptor (GPCR) that serves as a photoreceptor molecule in the retina. Absorption of a photon causes a structural change in the protein that initiates a signal transduction signal via its G-protein (transducin) that is processed by the vision system. Understanding the nature of the activation and signaling process requires molecular structural information for the activated receptor and its complexes. This information will be important for understanding the molecular basis for vision, but also for understanding the more general process of activation of GPCRs. GPCRs are a major family of membrane receptors that serve as drug targets for a large fraction of the commercially important pharmaceuticals. Just as our initial structure determination of rhodopsin affected the investigation and modeling of other GPCRs, the structure of activated rhodopsin and/or its complex with transducin will provide a basis for further development of therapeutic agents for this class of proteins.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本项目的目标是获得视紫红质及其与其他蛋白质复合物的晶体结构测定。 视紫红质是G蛋白偶联受体（GPCR），其在视网膜中充当感光分子。 光子的吸收引起蛋白质的结构变化，通过其G蛋白（transducin）启动信号转导信号，由视觉系统处理。 了解激活和信号传导过程的性质需要激活受体及其复合物的分子结构信息。 这些信息对于理解视觉的分子基础以及理解GPCR激活的更一般过程都很重要。 GPCR是膜受体的主要家族，其充当大部分商业上重要的药物的药物靶标。 正如我们最初对视紫红质的结构测定影响了对其他GPCR的研究和建模一样，活化视紫红质和/或其与转导素的复合物的结构将为进一步开发这类蛋白质的治疗剂提供基础。