Semi-volatile PCBs: Sources, Exposures, Toxicities

描述(由申请人提供) 爱荷华大学的超级基金基础研究计划(ISBRP)是一项共同努力，涉及生物医学和非生物医学研究领域的基础、机械和应用项目。该方案的总体主题是大气来源和接触半挥发性多氯联苯的后果，它涉及低卤代多氯联苯的挥发、运输和暴露，特别是那些与受污染的水、前工业场所、其他大气来源有关的多氯联苯，以及接触这些物质的后果。我们计划确定暴露的途径，着眼于预防或限制暴露并改善影响。ISBRP汇集了15名科学家，代表4所大学的5个系。他们将共同努力，测量多氯联苯的来源、运输和环境暴露(项目4和6)；它们在动物和人类中的分布、代谢和毒性(项目1、2和3)；以及植物修复的新方法(项目5)。研究包括一个以社区为基础的参与性研究项目--对生活或工作在芝加哥大都市区较低氯化多氯联苯来源附近的公民的暴露情况进行评估。我们喜欢芝加哥公民团体的合作，那里的许多少数族裔公民生活在贫困线以下，靠近去工业化的地点。我们的研究项目和整体效率得到了七个核心的支持-管理、合成、分析、吸入毒理学、培训、研究翻译和社区推广-通过这些核心，计划和项目管理员将监督协调、信息传输、实验设计和分析以及研究评估。评估过程在我们的8人外部咨询委员会的年度会议上达到顶峰。合成核心将合成所有要研究的化合物/混合物，而分析核心则提供从新陈代谢到运动的关键成分信息。社区外联和研究翻译核心将向各种利益攸关方传递研究成果，并让这些利益攸关方参与研究活动。培训核心和研究项目为20多名学生和博士后学者提供培训。总体而言，这一多学科计划带来了广泛的经验和专业知识，以应对与超级基金化学品相关的问题，这些问题对中西部和国家至关重要。

DESCRIPTION (provided by applicant) The Superfund basic research program at the University of Iowa (ISBRP) is a joint endeavor involving basic, mechanistic and applied projects in biomedical and non-biomedical research areas. The program's overall theme is the consequences of atmospheric sources and exposures to semi-volatile Polychlorinated Biphenyls (PCBs), and it deals with volatilization, transport and exposure of lower halogenated PCBs, especially those PCBs that are associated with contaminated waters, former industrial sites, other atmospheric sources, and the consequences of exposure to them. We plan to identify routes of exposure with an eye to preventing or limiting exposure and ameliorating the effects. The ISBRP brings together 15 scientists, representing 5 departments in 4 colleges. Working together, they will measure sources, transport and environmental exposure of PCBs (project #4 and #6); their distribution, metabolism and toxicity in animals and humans (project #1, #2 and #3); and novel methods of phytoremediation (project #5). Studies include a community-based participatory research project-an assessment of exposures to citizens who live or work in the vicinity of sources of lower chlorinated PCBs in the Chicago Metropolitan area. We enjoy the cooperation of citizen groups in Chicago, where many ethnic-minority citizens are living below the poverty line near deindustrialized sites. Our research projects and overall efficiency are supported by seven cores- Administration, Synthesis, Analytical, Inhalation Toxicology, Training, Research Translation and Community Outreach -through which program and project administrators will oversee coordination, information transfer, design and analysis of experiments, and assessment of research. The assessment process culminates in an annual meeting of our 8-member External Advisory Committee. The Synthesis Core will synthesize all compounds/mixtures to be studied while the Analytical Core provides critical compositional information from metabolism to movement. Community Outreach and Research Translation Cores will transmit research findings to a variety of stakeholders and involve those stakeholders in research activities. A Training Core and the research projects provide for the training of more than 20 students and postdoctoral scholars. Overall this multidisciplinary program brings abroad range of experience and expertise to bear on problems associated with Superfund chemicals that are critical to the Midwest and the nation.