Semi-volatile PCBs: Sources, Exposures, Toxicities

半挥发性多氯联苯：来源、暴露、毒性

• 批准号: 7479457
• 负责人: LARRY W ROBERTSON
• 金额: $ 1.22万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-12 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7479457
• 关键词: Address; Administrator; Advisory Committees; Animals; Area; Basic Science; Biochemical; Biomedical Research; Chicago; Communities; Community Outreach; Development; Endocrine; Environmental Exposure; Exposure to; Eye; Food; Funding; Goals; Health; Illinois; Intervention; Iowa; Joints; Life; Measures; Metabolism; Methods; Molecular; Movement; Organism; Outreach Research; Personal Satisfaction; Plants; Polychlorinated Biphenyls; Population; Poverty; Process; Process Assessment; Range; Reaction; Recommendation; Research; Research Activity; Research Project Grants; Risk; Route; Scientist; Site; Soil; Source; Students; Title; Toxic effect; Training; Translations; Universities; Ursidae Family; Volatilization; Water; Work; cellular targeting; college; community based participatory research; experience; feeding; improved; member; multidisciplinary; neurotoxicity; novel; novel strategies; pollutant; prevent; programs; remediation; superfund chemical; uptake

The Iowa/Illinois superfund basic research program (iisbrp) is a joint endeavor of the University of Iowa and the University of Illinois at Urbana-Champaign that involves basic, mechanistic and applied projects in biomedical and non-biomedical research areas. The program's overall theme is the consequences of atmospheric sources and exposures to semi-volatile Polychlorinated Biphenyls (PCBs), as expressed in the program title: "Semivolatile PCBs: Sources, Exposures, Toxicities." Ours is unlike any currently funded sbrp, in that it deals with volatilization, transport and exposure of lower halogenated PCBs, especially those PCBs that are associated with contaminated waters, building demolition, former industrial sites, other atmospheric sources, and the consequences of exposure to them. We plan to identify routes of exposure with an eye to preventing or limiting exposure and ameliorating the effects. The iisbrp brings together 22 scientists representing 9 departments in 7 colleges of 4 universities. Working together, we will measure sources, transport and environmental exposures of PCBs (Proj. 4,6,9); their distribution, metabolism and toxicity in animals {Proj. 1,2,3,7,8); and novel methods of phytoremediation (Proj. 5). Our studies include a community-based participatory research project¿an assessment of exposures to citizens who live or work in the vicinity of sources of lower chlorinated PCBs in south Chicago, IL, and East Chicago, IN. We enjoy the cooperation of citizen groups in those areas, where many ethnicminority citizens are living below the poverty line near de-industrialized sites. Our research projects and overall sbrp activities are supported by 6 cores¿Administration (A); Synthesis (B); Analytical (C), Training (D), Research Translation (E) and Community Outreach (F)¿through which program and project administrators will oversee coordination, information transfer, and assessment of research. The assessment process culminates in an annual meeting of our 7-member External Advisory Committee. The Synthesis Core will synthesize all compounds /mixtures to be studied while the Analytical Core will provide critical compositional information from metabolism to movement. Community Outreach and Research Translation Cores will transmit research findings to a variety of stakeholders and involve them in research activities. A Training Core and the research projects provide for the training of 20 students and postdoctoral scholars. Overall this multidisciplinary program brings a broad range of experience and expertise to bear on problems associated with Superfund chemicals that are critical to the Midwest and the nation.

爱荷华州/伊利诺伊州超级基金基础研究计划（iisbrp）是爱荷华州大学和 伊利诺伊大学厄巴纳-香槟分校，涉及生物医学和 非生物医学研究领域。该计划的总体主题是大气来源的后果 和接触半挥发性多氯联苯，如方案标题所述：“半挥发性 多氯联苯：来源，暴露，毒性。“我们的银行与目前资助的任何SBRP银行不同， 低卤化多氯联苯的挥发、迁移和接触，特别是那些与 受污染的沃茨、建筑物拆除、前工业场地、其他大气来源，以及 暴露于它们的后果。我们计划确定接触途径，以防止或限制 暴露和改善效果。iisbrp汇集了22名科学家代表9个部门在7 4所大学的学院。通过合作，我们将测量污染物的来源、运输和环境暴露， 多氯联苯（项目4，6，9）;它们在动物中的分布、代谢和毒性（Proj. 1，2，3，7，8）;和新的方法， 植物修复（项目）5）。我们的研究包括一个以社区为基础的参与性研究项目， 评估在南方低氯化多氯联苯来源附近生活或工作的公民的接触情况 伊利诺伊州芝加哥和印第安纳州东芝加哥。我们在这些地区享有公民团体的合作， 公民在非工业化地区附近生活在贫困线以下。我们的研究项目和整体 SBRP活动由6个核心支助：行政（A）;综合（B）;分析（C）;培训（D）;研究 翻译（E）和社区外展（F）通过这些项目和项目管理员将监督 协调、信息传递和研究评估。评估过程的高潮是每年一次的 我们的7人外部咨询委员会会议。合成核心将合成所有化合物 /混合物进行研究，而分析核心将提供从代谢到 运动社区外展和研究翻译核心将把研究结果传递给各种 并让他们参与研究活动。一个培训核心和研究项目提供了 培养20名学生和博士后学者。总体而言，这个多学科计划带来了广泛的 与超级基金化学品有关的问题，对 中西部和全国。