COBRE: OUHSC: ANIMAL CORE

COBRE：OUHSC：动物核心

• 批准号: 7959975
• 负责人: Michelle C Callegan
• 金额: $ 9.62万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959975
• 关键词: Animals; Area; Biohazardous Substance; Breeding; Centers of Research Excellence; Collaborations; Collection; Computer Retrieval of Information on Scientific Projects Database; Dark Adaptation; Development; Diabetes Mellitus; Digital Photography; Electroretinography; Environment; Equipment; Funding; Genes; Glaucoma; Grant; Growth; House mice; Immune; Institution; Insulin Receptor; Light; Mentors; Microinjections; Microsurgery; Oklahoma; Oryctolagus cuniculus; Rattus; Research; Research Personnel; Resources; Retinal Degeneration; Source; System; Transgenic Organisms; United States National Institutes of Health; Vision; Vision research; Vitrectomy; animal care; cytokine; programs; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Animal Module of the COBRE serves all vision researchers on the OUHSC campus with high-quality animal care and technical assistance with vision-related experiments. Housing for mice, rats, and rabbits includes conventional, microisolation, and biohazard environments. Equipment available in the Animal Module includes systems for electroretinography, microsurgery, microinjection, vitrectomy, dark adaptation, light exposure, and digital photography and videography. Transgenic breeding colonies have been developed and established, facilitating the analysis of specific genes and factors involved in retinal degeneration, glaucoma, insulin receptor, diabetes, cytokine synthesis, and innate immune recognition systems. This varied collection of transgenic strains is available to all vision and non-vision researchers at OUHSC and has facilitated fruitful collaborations among researchers in differing areas of expertise. The Animal Module is the most heavily used COBRE module and is absolutely essential to the research programs of the COBRE PJIs and ECIs. Growth of vision research at OUHSC and subsequent increases in animal needs necessitates expansion into additional animal space on the OUHSC campus. An estimated doubling of available animal space is projected at DMEI with the completion of facility expansion in the next 2 years. These major improvements will facilitate the development of the COBRE PJIs' and ECIs' research programs and the growth of vision research at OUHSC.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 COBRE的动物模块为OUHSC校园的所有视觉研究人员提供高质量的动物护理和视觉相关实验的技术援助。小鼠、大鼠和家兔的饲养环境包括常规、微隔离和生物危害环境。动物模块中可用的设备包括视网膜电图系统、显微手术、显微注射、玻璃体切除术、暗适应、曝光以及数字摄影和摄像。转基因育种集落已经开发和建立，促进参与视网膜变性、青光眼、胰岛素受体、糖尿病、细胞因子合成和先天免疫识别系统的特定基因和因子的分析。这种不同的转基因菌株集合可供OUHSC的所有视力和非视力研究人员使用，并促进了不同专业领域研究人员之间富有成效的合作。动物模块是使用最频繁的COBRE模块，对于COBRE PJIs和ECIs的研究计划来说是绝对必要的。在OUHSC的视觉研究的增长和动物需求的后续增长需要扩展到OUHSC校园额外的动物空间。随着未来2年设施扩建的完成，预计DMEI的可用动物空间将增加一倍。这些重大改进将促进COBRE PJIs和ECIs研究计划的发展以及OUHSC视觉研究的发展。