COBRE: LSU: ADMIN, MENTOR, RECRUIT & EVAL CORE: STROKE, NEURODEGEN DIS, BEHAV

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 行政、指导、征聘和评价核心将对该协调委员会的所有活动进行集中协调和监督。 LSU-HSC领导了四个路易斯安那州机构在COBRE神经科学研究中的合作伙伴关系。 项目主任和既定的科学家是导师选择，非常有前途的初级教师谁执行四个研究项目已被设计为指导建立新的国家竞争力的研究的共同目标。 科学重点是神经生物学的核心问题：了解突触可塑性和神经元存活的细胞和分子基础，这对澄清神经系统疾病（如中风，神经创伤和神经退行性疾病）的病理生理学至关重要。 这个多学科的计划涉及细胞神经生理学，分子生物学和行为神经科学。 为了支持COBRE项目，核心资源包括成像设施、脂质信使的神经化学和分子神经生物学。 第二至第五年的招聘计划进一步有利于合作机构，积极吸引新的研究人员，他们将在已建立的神经科学家的指导下工作。 所需的行政核心资金相对较少。 实现这些目标的具体目标是：1）通过研究项目促进教师发展; 2）通过招聘、启动、指导和留住新教师，进一步发展具有竞争力的校外资助调查人员的临界质量; 3）通过在LSUHSC开发三个核心研究模块，加强对扩大路易斯安那州神经科学能力至关重要的基础设施; 4）提供科学和宏观指导，加强促进互动的支持网络; 5）实施中期和成果评估，以保持COBRE计划的正常进行。 这种伙伴关系依赖于现有的专业知识和我们在路易斯安那州建立一个科学上成功的神经科学联盟的坚定决定。 四个目标教师和四个待招聘的教师是实现这些目标的关键基石。 核心资源对这个联盟的整体成功至关重要，不仅在神经科学领域，而且在所有生物医学科学领域。指导初级教师的计划和招聘计划将确保路易斯安那州新的具有全国竞争力的神经科学家源源不断。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Administrative, Mentoring, Recruitment and Evaluation Core will provide centralized coordination and oversight to all the activities of this COBRE. The LSU-HSC leads a partnership of four Louisiana institutions in a COBRE on neuroscience research. The Program Director and established scientists are mentors to selected, highly promising junior faculty who execute four research projects that have been designed for the common goal of mentoring to build new nationally competitive research. The scientific focus is on a central issue of neurobiology: to understand the cellular and molecular basis of synaptic plasticity and neuronal survival critical to clarify the pathophysiology of neurological disorders such as stroke, neural trauma and neurodegenerative diseases. This multidisciplinary program involves cellular neurophysiology, molecular biology and behavioral neuroscience. To support the COBRE projects, core resources include facilities for imaging, neurochemistry of lipid messengers and molecular neurobiology. A recruitment plan for years 2 to 5 further benefits the collaborating institutions by actively attracting new research faculty who will work under the guidance of established neuroscientists as mentors. A relatively small administrative core funding is requested. The specific aims to attain these objectives are 1) to promote faculty development through research projects; 2) to further develop a critical mass of competitive extramurally funded investigators by the recruitment, start up, mentoring and retention of new faculty members; 3) to enhance the infrastructure critical for expanding neuroscience capability in Louisiana by developing three core research modules at LSUHSC; 4) to provide scientific and grantsmanship mentoring and strengthen the support network that promotes interactions; and 5) to implement interim and outcome evaluations so as to keep this COBRE program on track. This partnership rests on existing expertise and in our firm decision to build a scientifically successful neuroscience alliance in Louisiana. The four target faculty and the four to-be-recruited faculty are the critical building blocks to achieve these goals. The core resources are vital to the overall success of this consortium, not only in neuroscience but in all the biomedical sciences. The plans for mentoring junior faculty and the recruitment plan will ensure a steady stream of new nationally competitive neuroscientists in Louisiana.