Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience

我们的十年COBRE，“指导路易斯安那州的神经科学”（p20rr016816,2002 -2012）已经成为我们地区神经科学研究发展的变革力量。它也使研究得以持续，尽管卡特里娜飓风和丽塔飓风。COBRE为启动8个独立的研究事业提供了指导和支持。基础设施的建立导致了10名独立科学家的招募。该P30 COBRE三期合同的重点是关键基础设施，包括(a)为LSUHSC、杜兰、Xavier和尼科尔斯州立大学的19个神经科学实验室提供核心支持；以及(b)试点项目，使研究人员能够达到R01和类似的拨款支持。指导和核心支持是过渡时期的中心主题，以实现核心的可持续性和进一步的成功。多光子共聚焦显微镜核心允许表征海马体中的树突整合。特别是，双扫描仪设置用于定义不同分布的突触输入，树突整合的形式，以及海马CA1神经元顶端树突的动作电位输出。中介体脂质组学核心在发现神经保护蛋白D1和开始定义大脑和其他组织中的炎症消退回路中是必不可少的。计算神经科学核心扩展了模拟和建模的优势。成像核心协助研究人员与国家的最先进的技术组织分析和细胞和分子成像。试点项目计划将通过为期一年的试点项目确定、支持和指导科学家。这些试点基金是我们未来可持续发展计划的基础。行政核心将提供指导团队和行政支持，实施和扩大多学科充实计划，支持合作，并评估和管理试点项目的有效性。我们相信，有了这些资源，我们将顺利过渡到一个持续的、杰出的、跨机构的神经科学卓越中心。

Our ten-year COBRE, "Mentoring Neuroscience in Louisiana" (P20RR016816, 2002-2012) has been a transformative force that provided growth of neuroscience research in our region. It also allowed to sustain research in spite of Hurricanes Katrina and Rita. The COBRE provided mentoring and support to launch eight independent research careers. The infrastructure created led to the recruitment of 10 independent scientists. This P30 COBRE Phase III award is focused on critical infrastructure that includes (a) Core support for 19 neuroscience laboratories at LSUHSC, Tulane, Xavier and Nicholls State University; and (b) pilot projects to enable investigators to achieve R01 and similar grant support. Mentoring and Core support are the central themes during the transitional period to attain sustainability of the Cores and further success. The Multiphoton Confocal Microscopy Core allows for characterization of dendritic integration in the hippocampus. In particular, the dual scanner set-up was used to define differently distributed syaptic input, the form of dendritic integration, and action potential output in the apical dendrites of hippocampal CA1 neurons. The Mediator Lipidomics Core was essential in the discovery of neuroprotectin D1 and in beginning to define inflammatory resolution circuits in the brain and other tissues. The Computational Neuroscience Core expands on strengths in simulation and modeling. The Imaging Core assists investigators with state-of-the- art technologies for tissue analysis and cellular and molecular imaging. The Pilot Project Program will identify, support and mentor scientists through one-year pilot projects. These pilot funds are fundamental to our plans for the future sustainability. The Administrative Core will provide mentoring teams and administrative support, implement and expand multidisciplinary enrichment programs, support collaborations, and evaluate and manage the effectiveness of pilot projects. We are confident that with these resources we will make a smooth transition to a sustained, outstanding, trans-institutional Center of Neuroscience Excellence.