Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience

十年来，我们一直致力于“指导路易斯安那州的神经科学”(P20RR016816,2002-2012)，这是一股变革性的力量，推动了我们地区神经科学研究的发展。它还允许在卡特里娜和丽塔飓风的情况下继续进行研究。科布雷提供了指导和支持，启动了八个独立的研究职业。建立的基础设施导致招募了10名独立科学家。P30 Cobre第三阶段奖的重点是关键基础设施，包括(A)为LSUHSC、杜兰、泽维尔和尼科尔斯州立大学的19个神经科学实验室提供核心支持；以及(B)使研究人员能够获得R01和类似赠款支持的试点项目。指导和核心支助是过渡时期实现核心可持续性和进一步取得成功的中心主题。多光子共聚焦显微镜核心可用于表征海马区的树突整合。特别是，双扫描仪的设置被用来定义不同分布的突触输入，树突整合的形式，以及在海马CA1神经元顶树突中的动作电位输出。中介脂质组学核心在神经保护素D1的发现和开始定义大脑和其他组织中的炎症分解回路方面是必不可少的。计算神经科学核心扩展了模拟和建模方面的优势。成像核心为研究人员提供最先进的组织分析、细胞和分子成像技术。试点项目计划将通过为期一年的试点项目来确定、支持和指导科学家。这些试点资金是我们未来可持续发展计划的基础。行政核心将提供指导团队和行政支持，实施和扩大多学科丰富方案，支持协作，并评估和管理试点项目的有效性。我们相信，有了这些资源，我们将平稳过渡到一个持续的、杰出的、跨机构的神经科学卓越中心。

Our ten-year COBRE, "Mentoring Neuroscience in Louisiana" (P20RR016816, 2002-2012) has been a transformative force that provided growth of neuroscience research in our region. It also allowed to sustain research in spite of Hurricanes Katrina and Rita. The COBRE provided mentoring and support to launch eight independent research careers. The infrastructure created led to the recruitment of 10 independent scientists. This P30 COBRE Phase III award is focused on critical infrastructure that includes (a) Core support for 19 neuroscience laboratories at LSUHSC, Tulane, Xavier and Nicholls State University; and (b) pilot projects to enable investigators to achieve R01 and similar grant support. Mentoring and Core support are the central themes during the transitional period to attain sustainability of the Cores and further success. The Multiphoton Confocal Microscopy Core allows for characterization of dendritic integration in the hippocampus. In particular, the dual scanner set-up was used to define differently distributed syaptic input, the form of dendritic integration, and action potential output in the apical dendrites of hippocampal CA1 neurons. The Mediator Lipidomics Core was essential in the discovery of neuroprotectin D1 and in beginning to define inflammatory resolution circuits in the brain and other tissues. The Computational Neuroscience Core expands on strengths in simulation and modeling. The Imaging Core assists investigators with state-of-the- art technologies for tissue analysis and cellular and molecular imaging. The Pilot Project Program will identify, support and mentor scientists through one-year pilot projects. These pilot funds are fundamental to our plans for the future sustainability. The Administrative Core will provide mentoring teams and administrative support, implement and expand multidisciplinary enrichment programs, support collaborations, and evaluate and manage the effectiveness of pilot projects. We are confident that with these resources we will make a smooth transition to a sustained, outstanding, trans-institutional Center of Neuroscience Excellence.