Understanding Racial and Ethnic Differences in Survival from Colorectal Cancer

了解结直肠癌生存率的种族和民族差异

• 批准号: 7938158
• 负责人: Chyke Abadama Doubeni
• 金额: $ 6.53万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-25 至 2011-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7938158
• 关键词: 20 year old; Age; Cancer Biology; Cancer Death Rates; Cancer Patient; Cancer Research Network; Caring; Case Fatality Rates; Cessation of life; Chronic; Colon Carcinoma; Colorectal; Colorectal Cancer; Consensus; Development Plans; Diagnosis; Diagnostic Neoplasm Staging; Enrollment; Epidemiology; Ethnic Origin; Foundations; Funding; Goals; Health Insurance; Health Services Accessibility; Healthcare Systems; Incidence; Insurance Coverage; Integrated Health Care Systems; Intervention; Knowledge; Literature; Malignant Neoplasms; Mediator of activation protein; Medical; Mentors; National Cancer Institute; Patients; Pattern; Patterns of Care; Policies; Population Heterogeneity; Prevention; Principal Investigator; Race; Research; Research Methodology; Research Personnel; Screening for cancer; Screening procedure; Series; Services; Socioeconomic Status; Source; Stage at Diagnosis; Survival Rate; Survivors; System; Time; Training; Translational Research; Tumor stage; United States; Woman; Work; Writing; base; cancer care; cancer diagnosis; career; career development; cohort; design; experience; men; mortality; patient population; programs; racial and ethnic disparities; racial/ethnic difference; research to practice; skills; socioeconomics

DESCRIPTION (provided by applicant): Colorectal cancers are the third most common invasive cancers among men and women in the United States. Improvements in prevention, screening and treatment have resulted in decreasing case-fatality rates from colorectal cancer since the 1980s. Paradoxically, disparities in survival from this cancer especially between Blacks and Whites have widened over time. Although there is no consensus in existing literature, current evidence suggests that factors related to access to health care including socioeconomic differences contribute to these disparities. The goal of the proposed research program is to identify potentially modifiable causes of disparities in cancer survival with a long range goal of reducing or eliminating the disproportionate burden of colorectal cancer among certain patient populations. The specific aims for this project are to: 1) compare colorectal cancer survival rates by race/ethnicity over the period 1993 through 2004; 2) compare the distribution of tumor stage at diagnosis for colorectal cancer by race/ethnicity; 3) examine potential mediators of the relationship of survival and race/ethnicity among colorectal cancer patients; 4) examine the patterns of care of survivors of colorectal cancer; and 5) explore the effect of socioeconomic status on the relationship between race/ethnicity and survival among colorectal cancer patients. This project will be conducted on a large racially diverse cohort comprised of patients 20 years and older diagnosed with colorectal cancer (1993 to 2004) while enrolled in one of four integrated health care systems that are affiliated with the National Cancer Institute-funded Cancer Research Network. This research plan is part of a career development program aimed at providing the training and experience needed for Dr. Doubeni to become an independently funded clinician-investigator focusing on disparities in cancer survival. The objectives of the career development plan are to acquire knowledge and skills in: 1) cancer biology, epidemiology and treatment; 2) advanced research methods; 3) scientific writing; and 4) the translation of research into practice and policy. The career development program will be accomplished through mentoring and targeted advanced courses. The studies encompassed under the proposed research program will make important contributions to our understanding of racial/ethnic differences in cancer survival rates. The proposed project will lay the foundation for the candidate's long-term career goal of designing system-based interventions aimed at eliminating disparities in cancer care and survival, a major objective of HealthyPeople 2010.

描述（由申请人提供）：结直肠癌是美国男性和女性中第三大最常见的侵袭性癌症。自1980年代以来，预防、筛查和治疗方面的改进使结直肠癌的病死率下降。矛盾的是，随着时间的推移，这种癌症的存活率差距越来越大，尤其是黑人和白人之间。虽然在现有文献中没有达成共识，但目前的证据表明，与获得卫生保健有关的因素，包括社会经济差异，造成了这些差异。拟议研究项目的目标是确定癌症生存差异的潜在可改变原因，以减少或消除某些患者群体中不成比例的结直肠癌负担。该项目的具体目标是：1)比较1993年至2004年期间不同种族/民族的结直肠癌存活率；2)比较不同种族结直肠癌诊断时肿瘤分期的分布；3)探讨结直肠癌患者生存与种族/民族关系的潜在中介因素；4)检查结直肠癌幸存者的护理模式；5)探讨社会经济地位对人种/民族与结直肠癌患者生存关系的影响。该项目将在一个由20岁及以上确诊为结直肠癌的患者（1993年至2004年）组成的大型种族多样化队列中进行，这些患者在隶属于国家癌症研究所资助的癌症研究网络的四个综合医疗保健系统之一中登记。该研究计划是职业发展计划的一部分，旨在为Doubeni博士提供所需的培训和经验，使其成为一名独立资助的临床研究员，专注于癌症生存差异。职业发展计划的目标是获得以下方面的知识和技能：1)癌症生物学、流行病学和治疗；2)先进的研究方法；3)科学写作；4)将研究成果转化为实践和政策。职业发展计划将通过指导和有针对性的高级课程来完成。拟议的研究项目所包含的研究将对我们理解癌症存活率的种族差异做出重要贡献。拟议的项目将为候选人的长期职业目标奠定基础，该目标是设计基于系统的干预措施，旨在消除癌症护理和生存方面的差异，这是HealthyPeople 2010年的主要目标。