DEVELOPMENT OF NEAR-INFRARED SPECTROSCOPY (NIRS) FOR RECORDING BRAIN FUNCTION DUR

用于记录大脑功能的近红外光谱 (NIRS) 的开发

• 批准号: 7930019
• 负责人: Theodore James Huppert
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7930019
• 关键词: Address; Affect; American; Area; Biomechanics; Biometry; Brain; Brain imaging; Brain region; Clinic; Cognitive; Communities; Complement; Detection; Development; Elderly; Environment; Equilibrium; Equipment; Functional Magnetic Resonance Imaging; Future; Gait; Head; Hemoglobin; Human; Image; Imaging technology; Individual; Investigation; Knowledge; Lateral; Light; Magnetic Resonance Imaging; Measures; Methodology; Methods; Morphologic artifacts; Motion; Movement; Musculoskeletal Equilibrium; Near-Infrared Spectroscopy; Parietal; Participant; Posture; Reaction; Relative (related person); Research; Resources; Role; Scheme; Signal Transduction; Simulate; Site; Solutions; Spectrum Analysis; Techniques; Technology; Testing; Translating; Translations; Weight-Bearing state; computerized data processing; imaging modality; improved; instrument; multidisciplinary; neuroimaging; research study; technology development; tool; volunteer; young adult

A central theme of the research within the Pittsburgh OAIC has been to characterize brain function related to mobility and balance using a multidisciplinary team and a combination of methods including biomechanics, cognitive testing, and functional neuroimaging. To date, several groups at this center and elsewhere have explored determinants of mobility using functional MRI. However, a major criticism of these studies is that the imaging activities were not done under weight-bearing conditions, which may substantially affect postural control and hence brain activation. While advancements have been made to simulate more realistic mobility conditions for the subject within the MRI scanner, it is unclear how well these approaches approximate real-world scenarios and unconstrained movements with upright posture. NIRS provides a solution to this problem by allowing brain imaging outside of the MRI scanner environment.

匹兹堡OAIC研究的一个中心主题是 通过使用多学科团队以及包括生物力学、认知测试和功能性神经成像在内的方法的组合，来表征与移动性和平衡相关的大脑功能。到目前为止，该中心和其他地方的几个小组已经使用功能性MRI探索了移动性的决定因素。 然而，对这些研究的一个主要批评是，成像活动不是在负重条件下进行的，这可能会严重影响姿势控制，从而影响大脑激活。虽然已经取得了进步，以模拟MRI扫描仪内受试者的更真实的移动条件，但尚不清楚这些方法在多大程度上近似真实世界场景和直立姿势的无约束运动。NIRS通过允许在MRI扫描仪环境之外进行脑成像来解决这个问题。