IMMUNE RESTORATION AND PROTECTION IN SIV-INFECTED LONG TERM NONPROGRESSORS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 本研究的目的是探讨SIVmac感染长期无进展者（LTNP）中国恒河猴（Ch Rh）的病毒控制和免疫保护机制。 这将通过对存档样本的回顾性分析以及对7例SIVmac 239感染的Ch Rh的前瞻性研究的组合来完成。我们假设免疫反应的广度、强度和特异性将区分进展者和LTNP。从Ch Rh LTNP获得的知识可能会为设计更有效的疫苗或新的治疗方法来对抗HIV-1感染提供启示。 具体目标是： SA 1）：比较SIV感染的进行性和LTNP Ch Rh猕猴的粘膜和全身淋巴组织中的功能性病毒特异性和先天性免疫应答。 SA 2）：检查和比较SIV感染的进展和LTNP Ch Rh猕猴的粘膜和全身淋巴组织中的基因调控。 SA 3）：检查LTNP和进展者中的病毒学因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to explore the mechanisms of virus control and immune protection in SIVmac-infected long term nonprogressors (LTNP) rhesus macaques of Chinese-origin (Ch Rh). This will be done by a combination of retrospective analysis of archived samples as well as prospective study on 7 SIVmac239-infected Ch Rh. We hypothesize that the breadth, magnitude and specificity of the immune responses will distinguish progressors and LTNP. The knowledge obtained from Ch Rh LTNP may provide implications to design more efficacious vaccines or novel therapeutic approaches to combat HIV-1 infection. The specific aims are: SA 1): To compare functional virus-specific and innate immune responses in both mucosal and systemic lymphoid tissues of SIV-infected progressing, and LTNP Ch Rh macaques. SA 2): To examine and compare gene regulation in mucosal and systemic lymphoid tissues of progressing and LTNP Ch Rh macaques infected with SIV. SA 3): To examine virologic factors in LTNP and progressors.