Small Animal Imaging Shared Resource

小动物影像共享资源（SAISR）是作为JCCC共享资源建立的， 2002年，推出微型PET扫描仪原型、微型CT、数字化全身放射自显影（DWBA）系统 和光学成像系统。2002年，12名JCCC教师组成了用户群。在过去五 多年来，所有最初的SAISR仪器都已更换;我们目前有一个专用的成像套件， 拥有一个新的microCT，两个microPET仪器，一个新的低温恒温器和DWBA系统，三个 生物发光/荧光光学成像仪器和Maestro光谱过滤荧光 系统所有仪器都是在机构支持下获得的。SAISR有一个专门的动物园， 脑血管造影研究。我们的用户群已经增长到44名教师谁执行超过14000 去年的影像实验来自七个项目领域的JCCC成员完成了86%的研究。 JCCC CCSG对SAISR的支持占SAISR运营预算的14%。2008年，SAISR将 搬进一个新的1500平方米。英尺位于加州纳米系统研究所大楼的成像实验室。这个设施 将包括一个专用的动物园，手术室，microPET，microCT，生物发光，荧光 和DWBA能力和邻近空间的回旋加速器专用于小动物成像研究， 用于放射化学设施。这一新的有形设施切实表明了机构对以下方面的支持： 特别是SAISR和JCCC。SAISR是“全方位服务”，提供教学“课堂” 成像仪器和动物处理方案的指导和培训，个人指导，在线 说明，成像程序的标准操作程序， 仪器仪表、数据存储和存档、数据检索和数据处理、工作人员现场数据检索 数据处理咨询和协助，所有用于microPET、microCT和 光学成像实验，麻醉剂，杂项用品（注射器，加热平台，手术 材料，免疫缺陷小鼠隔离器，SAISR设计的多模态成像室 数据分析软件）。还为动物方案的准备、放射治疗 安全批准、数据分析和呈现以及多模态图像的配准。所有仪器 由SAISR工作人员维护和校准。关键的工作人员，谁有一个长期的协会与JCCC， SAISR和研究人员提供技术援助、实验指导和专业知识。在 除了协助研究人员制定具体的实验方案外，SAISR还为 研究人员开发和翻译新的仪器，探针和造影剂，以及 协助进行生物分布、剂量测定和毒理学研究。（另请参见第6.2.3节共享 历史上的资源，描述，基本特征）。 代表八个癌症中心项目区的29名癌症中心成员利用了 小动物影像共享资源在报告期间。这是一个持续的共享 resource.

The Small Animal Imaging Shared Resource (SAISR) was established as a JCCC Shared Resource in 2002, with a prototype microPET scanner, a microCT, a digital whole body autoradiograpy (DWBA) system and an optical imaging system. Twelve JCCC faculty formed the user base in 2002. During the past five years all initial SAISR instrumentation has been replaced; we currently have a dedicated imaging suite that houses a new microCT, two microPET instruments, a new cryostat and DWBA system, three bioluminescence/fluorescence optical imaging instruments and a Maestro spectral filtering fluorescence system. All instrumentation was obtained with institutional support. The SAISR has a dedicated vivarium for bngitudinal imaging studies. Our user base has grown to 44 faculty members who performed over 14,000 imaging experiments last year. JCCC members from seven Program Areas performed 86% of these studies. JCCC CCSG support for the SAISR is 14% of the SAISR operating budget. During 2008 the SAISR will move into a new 1500-sq. ft. imaging laboratory in the California NanoSystems Institute building. This facility will include a dedicated vivarium, procedure rooms, microPETs, microCT, bioluminescence, fluorescence and DWBA capabilities and adjacent space for a cyclotron dedicated to small animal imaging research and for radiochemistry facilities. This new physical facility is a tangible demonstration of institutional support for the SAISR in particular and the JCCC in general. The SAISR is "full service," providing didactic "classroom" instruction and training in imaging instrumentation and animal handling protocols, individual instruction, online instruction, standard operating procedures for imaging procedures, on-line remote scheduling for instrumentation, data storage and archiving, data retrieval and data processing, on-site data retrieval for staff consultation and assistance in data processing, all probes and contrast reagents for microPET, microCT and optical imaging experiments, anesthetics, miscellaneous supplies (syringes, heating platforms, surgical materials, isolators for immunocompromised mice, multimodality imaging chambers designed by SAISR staff) and software for data analysis. Assistance is also provided for animal protocol preparation, radiation safety approval, data analysis and presentation and co-registration of multimodality images. All instruments are maintained and calibrated by SAISR staff. Critical staff, who have a long association with the JCCC, the SAISR and the investigators, provide both technical assistance and experimental guidance and expertise. In addition to assisting investigators with specific experimental protocols, the SAISR provides support to the investigators in the development and translation of new instrumentation, probes and contrast agents, and assists with biodistribution, dosimetry and toxicology studies. (Please also see Section 6.2.3 on Shared Resources in the History, Description, Essential Characteristics). 29 Cancer Center members representing eight Cancer Center Program Areas utilized the services of the Small Animal Imaging Shared Resource during the reporting period. This is a continuing shared resource.