Small Animal Imaging Shared Resource

小动物成像共享资源

• 批准号: 7944612
• 负责人: Harvey R. Herschman
• 金额: $ 24.35万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-02 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944612
• 关键词: Anesthesia procedures; Anesthetics; Animals; Archives; Area; Autoradiography; Biodistribution; Bioluminescence; Budgets; Calibration; California; Cancer Center; Cancer Center Support Grant; Characteristics; Computer software; Consultations; Contrast Media; Cyclotrons; Data; Data Analyses; Data Storage and Retrieval; Development; Equipment; Faculty; Fluorescence; Heating; Housing; Image; Imaging Techniques; Immunocompromised Host; Individual; Institutes; Instruction; Jonsson Comprehensive Cancer Center of University of California Los Angeles; Laboratories; Mus; Optics; Positron-Emission Tomography; Preparation; Procedures; Protocols documentation; Radiation; Radiochemistry; Reagent; Recording of previous events; Reporting; Research; Research Personnel; Research Project Grants; Resource Sharing; Safety; Schedule; Services; Site; Small Animal Imaging Shared Resource; Syringes; System; Toxicology; Training; Translations; base; computerized data processing; cryostat; design; digital; dosimetry; imaging modality; imaging probe; instrument; instrumentation; member; multimodality; nanosystems; optical imaging; programs; prototype; research study; square foot; surgery material

The Small Animal Imaging Shared Resource (SAISR) was established as a JCCC Shared Resource in 2002, with a prototype microPET scanner, a microCT, a digital whole body autoradiograpy (DWBA) system and an optical imaging system. Twelve JCCC faculty formed the user base in 2002. During the past five years all initial SAISR instrumentation has been replaced; we currently have a dedicated imaging suite that houses a new microCT, two microPET instruments, a new cryostat and DWBA system, three bioluminescence/fluorescence optical imaging instruments and a Maestro spectral filtering fluorescence system. All instrumentation was obtained with institutional support. The SAISR has a dedicated vivarium for bngitudinal imaging studies. Our user base has grown to 44 faculty members who performed over 14,000 imaging experiments last year. JCCC members from seven Program Areas performed 86% of these studies. JCCC CCSG support for the SAISR is 14% of the SAISR operating budget. During 2008 the SAISR will move into a new 1500-sq. ft. imaging laboratory in the California NanoSystems Institute building. This facility will include a dedicated vivarium, procedure rooms, microPETs, microCT, bioluminescence, fluorescence and DWBA capabilities and adjacent space for a cyclotron dedicated to small animal imaging research and for radiochemistry facilities. This new physical facility is a tangible demonstration of institutional support for the SAISR in particular and the JCCC in general. The SAISR is "full service," providing didactic "classroom" instruction and training in imaging instrumentation and animal handling protocols, individual instruction, online instruction, standard operating procedures for imaging procedures, on-line remote scheduling for instrumentation, data storage and archiving, data retrieval and data processing, on-site data retrieval for staff consultation and assistance in data processing, all probes and contrast reagents for microPET, microCT and optical imaging experiments, anesthetics, miscellaneous supplies (syringes, heating platforms, surgical materials, isolators for immunocompromised mice, multimodality imaging chambers designed by SAISR staff) and software for data analysis. Assistance is also provided for animal protocol preparation, radiation safety approval, data analysis and presentation and co-registration of multimodality images. All instruments are maintained and calibrated by SAISR staff. Critical staff, who have a long association with the JCCC, the SAISR and the investigators, provide both technical assistance and experimental guidance and expertise. In addition to assisting investigators with specific experimental protocols, the SAISR provides support to the investigators in the development and translation of new instrumentation, probes and contrast agents, and assists with biodistribution, dosimetry and toxicology studies. (Please also see Section 6.2.3 on Shared Resources in the History, Description, Essential Characteristics). 29 Cancer Center members representing eight Cancer Center Program Areas utilized the services of the Small Animal Imaging Shared Resource during the reporting period. This is a continuing shared resource.

小动物成像共享资源 (SAISR) 是作为 JCCC 共享资源在 2002 年，推出 microPET 扫描仪原型、microCT、数字全身放射自显影 (DWBA) 系统 和光学成像系统。 2002 年，12 名 JCCC 教员组成了用户群。在过去的五年中 年所有最初的 SAISR 仪器均已更换；我们目前有一个专用的成像套件 拥有一台新的 microCT、两台 microPET 仪器、一台新的低温恒温器和 DWBA 系统、三台 生物发光/荧光光学成像仪器和 Maestro 光谱过滤荧光 系统。所有仪器都是在机构支持下获得的。 SAISR 有一个专门的动物园 腹部影像学研究。我们的用户群已发展到 44 名教职人员，他们的表演次数超过 14,000 去年的成像实验。来自七个计划领域的 JCCC 成员完成了 86% 的研究。 JCCC CCSG 对 SAISR 的支持占 SAISR 运营预算的 14%。 2008 年，SAISR 将 搬入新的 1500 平方英尺ft. 加州纳米系统研究所大楼的成像实验室。这个设施 将包括专用的饲养室、手术室、microPET、microCT、生物发光、荧光 和 DWBA 能力以及用于小动物成像研究和回旋加速器的邻近空间 用于放射化学设施。这个新的实体设施是机构支持的具体体现 特别是 SAISR，一般而言是 JCCC。 SAISR 提供​​“全方位服务”，提供教学“课堂” 成像仪器和动物处理方案的指导和培训，单独指导，在线 指令、成像程序的标准操作程序、在线远程调度 仪器仪表、数据存储和归档、数据检索和数据处理、工作人员现场数据检索 数据处理、所有探针和造影剂方面的咨询和协助，用于 microPET、microCT 和 光学成像实验、麻醉剂、杂项用品（注射器、加热平台、手术 材料、免疫功能低下小鼠的隔离器、SAISR 设计的多模态成像室 人员）和数据分析软件。还为动物方案准备、辐射提供协助 安全批准、数据分析和呈现以及多模态图像的共同注册。所有仪器 由 SAISR 工作人员维护和校准。与 JCCC 有着长期合作关系的关键人员， SAISR 和研究人员提供技术援助、实验指导和专业知识。在 除了协助研究人员制定具体的实验方案外，SAISR 还为 开发和翻译新仪器、探针和造影剂的研究人员，以及 协助生物分布、剂量测定和毒理学研究。 （另请参阅第 6.2.3 节“共享” 历史、描述、基本特征中的资源）。 代表 8 个癌症中心计划领域的 29 名癌症中心成员利用了 报告期内的小动物成像共享资源。这是一个持续的共享 资源。