Pathology Core

项目总结(见说明)： 由子宫内膜癌孢子组成的个人研究项目需要采购， 手术切除的正常子宫内膜组织和子宫内膜癌组织的加工和显微分析 子宫切除标本。此外，几个孢子项目提出了动物模型研究，将 需要对大鼠和小鼠子宫组织进行组织学处理和仔细的病理评估。在这 建议，Core将继续积极致力于高质量的子宫内膜翻译研究 癌症始于2003年最初的孢子资助。自2003年以来，戈尔一直为子宫内膜提供 向20名不同的调查人员提供组织和病理专业知识，其中9人不在MDACC范围内。这些 从2003年开始的合作已经产生了57份出版物和2份NIH/NCI R01赠款，其中 研究对象为子宫内膜癌患者。重要的是，核心热情地支持 学习翻译研究的实习生；23名不同的实习生(9名不同的实习生导师) 自2003年以来提供核心资源和专业知识。 为这一核心提出了以下具体目标。目标1是保持冰冻和石蜡包埋 子宫内膜癌、增生症和正常子宫内膜样本的组织储存库。目标2 为孢子项目中使用的所有临床标本和相关的 临床试验，并在必要时提供组织病理学技术服务。这包括组织学 拟建立的小鼠和大鼠子宫组织的加工和显微评价 在几个项目中进行试验。目标3是建立从患者的血/尿/腹水收集 子宫内膜癌和子宫内膜增生症患者行子宫切除术 非子宫内膜病变的子宫切除术(子宫肌瘤、宫颈不典型增生、子宫内膜异位症)。是这样的 液体将为未来子宫内膜诊断/预后标志物的测试提供资源 癌症。目标4是为所有冷冻和石蜡包埋的子宫内膜组织创建和维护一个数据库 和地核收集的液体。

PROJECT SUMMARY (See instructions): The individual researcin projects comprising this Endometrial Cancer SPORE require the procurement, processing, and microscopic analysis of normal endometrial tissues and endometrial cancers from surgical hysterectomy specimens. In addition, several of the SPORE projects propose animal model studies that will require histological processing and careful pathological assessment of rat and mouse uterine tissues. In this proposal, the Core will continue its active commitment to high-quality translational research in endometrial cancer that began with initial SPORE funding in 2003. Since 2003, the Gore has provided endometrial tissues and pathological expertise to 20 different investigators, 9 of which were outside of MDACC. These collaborations beginning in 2003 have resulted in 57 publications and 2 NIH/NCI R01 grants in which Core materials from endometrial cancer patients were used. Importantly, the Core enthusiastically supports trainees in learning translational research; 23 different trainees (9 different trainee mentors) have been provided with Core resources and expertise since 2003. The following Specific Aims are proposed for this Core. Aim 1 is to maintain a frozen and paraffinembedded tissue repository of endometrial cancers, hyperplasias, and normal endometrial samples. Aim 2 is to provide pathological review for all clinical specimens utilized in the SPORE projects and for related clinical trials and to provide histopathological technical services as necessary. This includes histological processing and microscopic evaluation of uterine tissues derived from the proposed mouse and rat experiments in several projects. Aim 3 is to establish a blood/urine/ascites fluid collection from patients undergoing hysterectomy for endometrial cancer and endometrial hyperplasia and from patients undergoing hysterectomy for non-endometrial pathology (uterine leiomyomas, cervix dysplasia, endometriosis). Such fluids will provide resources for the future testing of putative diagnostic/prognostic markers for endometrial cancer. Aim 4 is to create and maintain a database for all frozen and paraffin-embedded endometrial tissues and fluids collected by the Core.