PATHOGENIC MECH IN IDIOPATHIC CHRONIC DIARRHEA OF RH MACAQUES AT THE CNPRC

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 慢性特发性腹泻（ICD）是圈养猕猴管理中的一个主要健康和经济问题。 除了在不存在公认的肠道病原体的情况下结肠炎性细胞浸润的组织学表征外，尚未充分研究这种疾病的致病机制。 该项目的目标是系统地研究潜在的发病机制，包括食物过敏，对正常肠道细菌的过敏，以及结肠微生物群组成的不规则性（生态失调），在这种情况下的发展。 该项目还将研究膳食补充锌和/或可溶性纤维在治疗和预防ICD中的治疗潜力。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chronic idiopathic diarrhea (ICD) is a major health and economic problem in the management of rhesus monkeys in captivity. The pathogenic mechanism(s) underlying this condition have not been well studied beyond histological characterization of the colonic inflammatory cellular infiltrate in the absence of recognized enteric pathogens. The goal of this project is to systematically investigate potential pathogenetic mechanisms, including food hypersensitivity, hypersensitivity to normal gut commensal bacteria, and irregularities in composition of colonic microflora (dysbiosis), in the development of this condition. This project will also investigate the therapeutic potential of dietary supplementation with zinc and/or soluble fiber in the treatment and prevention of ICD.