PRODUCTION OF PEDIGREED SPF RHESUS MACAQUES: AIDS

纯种 SPF 恒河猴的生产：艾滋病

• 批准号: 8356902
• 负责人: NICHOLAS WILLIAM LERCHE
• 金额: $ 122.28万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-15 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356902
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Birth; Breeding; Cercopithecine Herpesvirus 1; Cytomegalovirus; Derivation procedure; Funding; Genotype; Goals; Grant; Infant; Macaca mulatta; Mothers; National Center for Research Resources; Nurseries; Principal Investigator; Production; Research; Research Infrastructure; Resources; Rhadinovirus; SIV; Simian Foamy Virus; Source; Specific Pathogen Frees; Type D Retrovirus; United States National Institutes of Health; Viral; Viral Pathogenesis; Virus; cost; genetic pedigree; germ free condition; public health relevance; vaccine development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The goal of this proposal is to continue to expand the production of genetically characterized rhesus macaques of Indian-ancestry that are specific pathogen-free (SPF) for seven persistent viruses, including simian immunodeficiency virus (SIV), simian type D retrovirus (SRV), simian T-lymphotropic virus (STLV), Cercopithecine herpesvirus 1 (B virus), simian foamy virus (SFV), rhesus cytomegalovirus (RhCMV) and rhesus rhadinovirus (RRV). This proposed expansion will be geared to the production of SPF animals for use in AIDS-related research, and to establishing a long-term self-sustaining SPF breeding colony of Indian- origin rhesus macaques with known pedigree and well-defined MHC genotypes. This colony now exceeds 350 animals and is self-sustaining through natural birth and rearing by SPF mothers. Derivation of SPF breeders through nursery-rearing of infants born to conventional breeders is no longer required. PUBLIC HEALTH RELEVANCE (provided by applicant): The rhesus monkeys produced as part of this grant will provide valuable resources for AIDS-related research. These animals will be used for research related to viral pathogenesis, vaccine development and anti-viral therapy.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 描述(由申请人提供)：这项建议的目标是继续扩大印度血统恒河猴的生产，这些恒河猴对七种持久病毒，包括猴免疫缺陷病毒(SIV)、猴D型逆转录病毒(SRV)、猴T淋巴组织病毒(STLV)、脑炎疱疹病毒1(B病毒)、猴泡沫病毒(SFV)、恒河猴巨细胞病毒(RhCMV)和恒河猴大疱疹病毒(RRV)具有特定病原体(SPF)。这项拟议的扩展将用于生产用于艾滋病相关研究的SPF动物，并建立一个长期自给自足的印度原生恒河猴繁育群体，这些恒河猴具有已知的谱系和明确的MHC基因类型。这个群体现在超过350只动物，并通过自然分娩和SPF母亲的饲养自给自足。不再需要通过对传统育种者所生婴儿的育儿来衍生SPF育种者。 公共卫生相关性(由申请者提供)：作为这笔赠款的一部分，培育的恒河猴将为艾滋病相关研究提供宝贵的资源。这些动物将用于与病毒发病机制、疫苗开发和抗病毒治疗相关的研究。