PRODUCTION OF PEDIGREED SPF RHESUS MACAQUES: AIDS

纯种 SPF 恒河猴的生产：艾滋病

• 批准号: 8356902
• 负责人: NICHOLAS WILLIAM LERCHE
• 金额: $ 122.28万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-15 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8356902
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Birth; Breeding; Cercopithecine Herpesvirus 1; Cytomegalovirus; Derivation procedure; Funding; Genotype; Goals; Grant; Infant; Macaca mulatta; Mothers; National Center for Research Resources; Nurseries; Principal Investigator; Production; Research; Research Infrastructure; Resources; Rhadinovirus; SIV; Simian Foamy Virus; Source; Specific Pathogen Frees; Type D Retrovirus; United States National Institutes of Health; Viral; Viral Pathogenesis; Virus; cost; genetic pedigree; germ free condition; public health relevance; vaccine development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The goal of this proposal is to continue to expand the production of genetically characterized rhesus macaques of Indian-ancestry that are specific pathogen-free (SPF) for seven persistent viruses, including simian immunodeficiency virus (SIV), simian type D retrovirus (SRV), simian T-lymphotropic virus (STLV), Cercopithecine herpesvirus 1 (B virus), simian foamy virus (SFV), rhesus cytomegalovirus (RhCMV) and rhesus rhadinovirus (RRV). This proposed expansion will be geared to the production of SPF animals for use in AIDS-related research, and to establishing a long-term self-sustaining SPF breeding colony of Indian- origin rhesus macaques with known pedigree and well-defined MHC genotypes. This colony now exceeds 350 animals and is self-sustaining through natural birth and rearing by SPF mothers. Derivation of SPF breeders through nursery-rearing of infants born to conventional breeders is no longer required. PUBLIC HEALTH RELEVANCE (provided by applicant): The rhesus monkeys produced as part of this grant will provide valuable resources for AIDS-related research. These animals will be used for research related to viral pathogenesis, vaccine development and anti-viral therapy.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 描述（申请人提供）：该提案的目标是继续扩大具有遗传特征的印度血统恒河猴的生产，这些恒河猴对7种持续存在的病毒无特异性病原体（SPF），包括猿猴免疫缺陷病毒（SIV）、猿猴D型逆转录病毒（SRV）、猿猴T淋巴细胞病毒（STLV）、猕猴疱疹病毒1型（B病毒）、猿猴泡沫病毒（SFV）、恒河猴巨细胞病毒（RhCMV）和恒河猴鼻状病毒（RRV）。这一拟议的扩展将适合于生产SPF动物用于艾滋病相关研究，并建立一个长期自我维持的SPF繁殖群的印度起源的恒河猴与已知的血统和明确的MHC基因型。这个群体现在超过350只动物，通过自然分娩和SPF母亲的养育而自我维持。不再需要通过托儿所养育传统育种者所生婴儿来获得SPF育种者。 公共卫生相关性（由申请人提供）：作为该赠款的一部分生产的恒河猴将为艾滋病相关研究提供宝贵的资源。这些动物将用于与病毒发病机制、疫苗开发和抗病毒治疗相关的研究。