PRODUCTION OF PEDIGREED SPF RHESUS MACAQUES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。次级项目的主要支助 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 为子项目列出的总成本可能 表示子项目使用的中心基础设施的估计数量， NCRR赠款不直接向子项目或子项目工作人员提供资金。 在艾滋病相关研究中，持续需要没有特定病原体，特别是持续性病毒感染的印度血统恒河猴。我们已经成功地建立和维持了一个长期的SPF繁殖群，遗传特征为印度恒河猴。目前的殖民地普查是302动物。到目前为止，该殖民地生产的148只动物已提供给各机构的艾滋病研究人员。 在该群体中生产的动物是猴疱疹病毒1型（CHV 1）、猿猴D型逆转录病毒（SRV）、猿猴免疫缺陷病毒（SIV）、猿猴嗜T淋巴细胞病毒（STLV）和猿猴泡沫病毒（SFV）的SPF。所有的动物都是已知的 血统和地理起源。还对产生的后代进行几种MHC I类（Mamu A*01、A*02、A*08、B*01、B*17）和II类（DPB、DQA、DQ B）基因座的单倍型分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. There is a continuing need for rhesus macaques of Indian-ancestry that are free of specific pathogens, particularly persistent viral infections, for use in AIDS-related research. We have successfully established and maintained a long-term breeding colony of SPF, genetically characterized Indian origin rhesus macaques. The current colony census is 302 animals. To date, 148 animals produced in this colony have been made available to AIDS researchers at various institutions. Animals produced in this colony are SPF for Cercopithecine herpesvirus 1 (CHV1), simian type D retrovirus (SRV), simian immunodeficiency virus (SIV), simian T- lymphotropic Virus (STLV) and simian foamy virus (SFV). All animals are of known pedigree and geographic origin. Offspring produced are also haplotyped for several MHC class I (Mamu A*01, A*02, A*08, B*01, B*17) and class II (DPB, DQA, DQB) loci.