PATHOGENIC MECH IN IDIOPATHIC CHRONIC DIARRHEA OF RH MACAQUES AT THE CNPRC

CNPRC 猕猴特发性慢性腹泻的致病机制

• 批准号: 8357345
• 负责人: NICHOLAS WILLIAM LERCHE
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357345
• 关键词: California; Chronic; Development; Diarrhea; Dietary Supplementation; Food Hypersensitivity; Funding; Goals; Grant; Hypersensitivity; Inflammatory; Leucocytic infiltrate; Macaca; Macaca mulatta; National Center for Research Resources; Prevention; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Therapeutic; United States National Institutes of Health; Zinc; commensal microbes; cost; enteric pathogen; health economics; soluble fiber

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Chronic idiopathic diarrhea (ICD) is a major health and economic problem in the management of rhesus monkeys in captivity. The pathogenic mechanism(s)underlying this condition have not been well studied beyond histological characterization of the colonic inflammatory cellular infiltrate in the absence of recognized enteric pathogens. The goal of this project is to systematically investigate potential pathogenetic mechanisms, including food hypersensitivity, hypersensitivity to normal gut commensal bacteria, and irregularities in composition of colonic microflora (dysbiosis), in the development of this condition. This project will also investigate the therapeutic potential of dietary supplementation with zinc and/or soluble fiber in the treatment and prevention of ICD.

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 慢性特发性腹泻(ICD)是圈养猕猴管理中的一个主要健康和经济问题。这种情况下的致病机制(S)除了在没有公认的肠道病原体的情况下结肠炎性细胞浸润的组织学特征外，还没有得到很好的研究。本项目的目标是系统地研究在这种情况下的潜在致病机制，包括食物超敏反应、对正常肠道共生菌的超敏反应以及结肠微生物群组成的异常(生态失调)。本项目还将研究膳食补充锌和/或可溶性纤维在ICD治疗和预防中的治疗潜力。