METHAMPHETAMINE, STRESS AND SIV: EFFECTS AT BLOOD-BRAIN BARRIER AND LYMPH NODES

甲基苯丙胺、压力和 SIV：对血脑屏障和淋巴结的影响

• 批准号: 8172555
• 负责人: JOHN P CAPITANIO
• 金额: $ 15.21万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172555
• 关键词: Adrenergic Agents; Blood; Blood - brain barrier anatomy; Computer Retrieval of Information on Scientific Projects Database; Funding; Gene Expression; Grant; Institution; Interferon Type I; Methamphetamine; Monkeys; Pattern; Permeability; Play; Recombinant Interferon Beta; Research; Research Personnel; Resources; Role; SIV; Source; Stress; United States National Institutes of Health; adrenergic; lymph nodes; nerve supply

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this project are 1) to examine the role played by methamphetamine and stress in alterations in innervation patterns, Type I interferon gene expression, and SIV replication in lymph nodes, and AIDS-related indicators in blood. 2) to examine the role played by methamphetamine and stress in altering permeability of the blood-brain barrier (BBB) in SIV infected monkeys, and 3) to examine whether beta adrenergic blockade or administration of recombinant interferon-beta (rIFN-b) will abrogate the effects of methamphetamine in lymph nodes and at the BBB.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 本研究的目的是：1）研究甲基苯丙胺和应激在神经支配模式、I型干扰素基因表达、SIV在淋巴结中的复制以及血液中艾滋病相关指标的改变中所起的作用。2)检查甲基苯丙胺和应激在改变SIV感染猴的血脑屏障（BBB）的渗透性中所起的作用，和3）检查β肾上腺素能阻断或重组干扰素-β（rIFN-b）的施用是否将消除甲基苯丙胺在淋巴结和血脑屏障中的作用。