METHAMPHETAMINE, STRESS AND SIV: EFFECTS AT BLOOD-BRAIN BARRIER AND LYMPH NODES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 本项目的目标是：1)研究甲基苯丙胺和应激在神经支配模式、I型干扰素基因表达、淋巴结中SIV复制和血液中艾滋病相关指标的变化中所起的作用。2)研究甲基苯丙胺和应激在SIV感染猴血脑屏障(BBB)通透性改变中的作用；3)研究β肾上腺素能受体阻滞剂或给予重组干扰素-β(rIFN-b)是否能消除甲基苯丙胺对淋巴结和血脑屏障通透性的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objectives of this project are 1) to examine the role played by methamphetamine and stress in alterations in innervation patterns, Type I interferon gene expression, and SIV replication in lymph nodes, and AIDS-related indicators in blood. 2) to examine the role played by methamphetamine and stress in altering permeability of the blood-brain barrier (BBB) in SIV infected monkeys, and 3) to examine whether beta adrenergic blockade or administration of recombinant interferon-beta (rIFN-b) will abrogate the effects of methamphetamine in lymph nodes and at the BBB.