METHAMPHETAMINE, STRESS AND SIV: EFFECTS AT BLOOD-BRAIN BARRIER AND LYMPH NODES

甲基苯丙胺、压力和 SIV：对血脑屏障和淋巴结的影响

• 批准号: 8357280
• 负责人: JOHN P CAPITANIO
• 金额: $ 19.14万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357280
• 关键词: Acquired Immunodeficiency Syndrome; Adrenergic Agents; Blood; Blood - brain barrier anatomy; California; Funding; Gene Expression; Grant; Interferon Type I; Methamphetamine; Monkeys; National Center for Research Resources; Pattern; Permeability; Play; Primates; Principal Investigator; Recombinant Interferon Beta; Research; Research Infrastructure; Resources; Role; SIV; Source; Stress; United States National Institutes of Health; adrenergic; cost; lymph nodes; nerve supply

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The objectives of this project are 1) to examine the role played by methamphetamine and stress in alterations in innervation patterns, Type I interferon gene expression, and SIV replication in lymph nodes, and AIDS-related indicators in blood. 2) to examine the role played by methamphetamine and stress in altering permeability of the blood-brain barrier (BBB) in SIV infected monkeys, and 3) to examine whether beta adrenergic blockade or administration of recombinant interferon-beta (rIFN-b) will abrogate the effects of methamphetamine in lymph nodes and at the BBB.

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