Blood and Tissue

血液和组织

• 批准号: 8015049
• 负责人: Karen L Furie
• 金额: $ 7.83万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-20 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8015049
• 关键词: Biological Markers; Blood; Blood specimen; Center for Translational Science Activities; Clinical; Clinical Trials; Collaborations; Collection; Communities; DNA; Ensure; Funding; Future; General Hospitals; Genetic; Genetic Materials; Hemorrhage; Hemostatic Agents; Human; Infarction; Inflammatory; International; Laboratories; Massachusetts; Monitor; NIH Program Announcements; National Institute of Neurological Disorders and Stroke; Plasma; Process; Research; Resources; Role; Sampling; Specimen; Stroke; Surrogate Endpoint; Tissues; Translational Research; Work; acute stroke; clinical practice; design; programs; repository; response; thrombolysis

The Blood and Tissue Core provides an essential resource for local and collaborative research. The Core is designed to exist as a "core without walls". The primary responsibility ofthe Core is to ensure the quality of processing and storage of human specimens. We work closely with the Massachusetts General Hospital's NIH-funded Chnical Research Center (CRC) which is part of the Harvard Clinical and Translational Science Center (CTSC), and we have established collaboration with Dr. James Liao's laboratory at the BWH. We propose a Blood and Tissue Core responsive to the aims set forth in the Specialized Program of Translational Research in Acute Stroke program announcement (PAR-09-254), which will support ARISE (project #2) at MGH and Neu-START at BWH, and collect and share plasma and DNA samples within the SPOTRIAS network. The aims ofthe Partners SPOTRIAS Blood and Tissue Core are: 1. To process, maintain, and distribute blood specimens collected in ARISE (Project #2) at MGH. 2. To support blood collection and processing for the Neu-START study at the BWH. 3. To store blood specimens collected on SPOTRIAS subjects for future collaborative studies. 4. To collect genetic material for submission to the NINDS repository for use in future genetic studies proposed within Partners, the SPOTRIAS network, the International Stroke Genetics Consortium (ISGC), and the broader scientific community.

血液和组织核心为当地和合作研究提供了必要的资源。核心被设计为“没有墙壁的核心”。核心的主要职责是确保人体标本的处理和储存质量。我们与马萨诸塞州总医院的NIH资助的临床研究中心（CRC）密切合作，该中心是哈佛临床和转化科学中心（CTSC）的一部分，我们与BWH的James Liao博士的实验室建立了合作关系。我们提出了一个血液和组织核心，以响应急性卒中转化研究专业项目公告（PAR-09-254）中提出的目标，该项目将支持MGH的ARISE（项目#2）和BWH的Neu-START，并在SPOTRIAS网络内收集和共享血浆和DNA样本。 合作伙伴SPOTRIAS血液和组织核心的目标是： 1.处理、保存和分发在MGH的ARISE（项目#2）中采集的血液标本。 2.支持BWH Neu-START研究的血液采集和处理。 3.储存从SPOTRIAS受试者中采集的血液标本，用于未来的合作研究。 4.收集遗传材料，提交至NINDS储存库，用于合作伙伴、SPOTRIAS网络、国际卒中遗传学联盟（ISGC）和更广泛的科学界提出的未来遗传学研究。