Blood and Tissue

血液和组织

• 批准号: 8377956
• 负责人: Karen L Furie
• 金额: $ 7.95万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-20 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8377956
• 关键词: Biological Markers; Blood; Blood specimen; Center for Translational Science Activities; Clinical Sciences; Clinical Trials; Collaborations; Collection; Communities; DNA; Ensure; Funding; Future; General Hospitals; Genetic; Genetic Materials; Hemorrhage; Hemostatic Agents; Human; Infarction; Inflammatory; International; Laboratories; Massachusetts; Monitor; NIH Program Announcements; National Institute of Neurological Disorders and Stroke; Plasma; Process; Research; Resources; Role; Sampling; Specimen; Stroke; Surrogate Endpoint; Tissues; Translational Research; United States National Institutes of Health; Work; acute stroke; clinical practice; design; programs; repository; response; thrombolysis

The Blood and Tissue Core provides an essential resource for local and collaborative research. The Core is designed to exist as a "core without walls". The primary responsibility ofthe Core is to ensure the quality of processing and storage of human specimens. We work closely with the Massachusetts General Hospital's NIH-funded Chnical Research Center (CRC) which is part of the Harvard Clinical and Translational Science Center (CTSC), and we have established collaboration with Dr. James Liao's laboratory at the BWH. We propose a Blood and Tissue Core responsive to the aims set forth in the Specialized Program of Translational Research in Acute Stroke program announcement (PAR-09-254), which will support ARISE (project #2) at MGH and Neu-START at BWH, and collect and share plasma and DNA samples within the SPOTRIAS network. The aims ofthe Partners SPOTRIAS Blood and Tissue Core are: 1. To process, maintain, and distribute blood specimens collected in ARISE (Project #2) at MGH. 2. To support blood collection and processing for the Neu-START study at the BWH. 3. To store blood specimens collected on SPOTRIAS subjects for future collaborative studies. 4. To collect genetic material for submission to the NINDS repository for use in future genetic studies proposed within Partners, the SPOTRIAS network, the International Stroke Genetics Consortium (ISGC), and the broader scientific community.

血液和组织核心为本地和合作研究提供了必要的资源。核心被设计成一个“没有围墙的核心”。核心的主要责任是确保人体标本的处理和存储质量。我们与麻省总医院NIH资助的临床研究中心(CRC)密切合作，该中心是哈佛临床和转化科学中心(CTSC)的一部分，我们还与BWH的James Liao博士的实验室建立了合作关系。我们提出了一个血液和组织核心，以响应急性卒中转化性研究计划公告(PAR-09-254)中提出的目标，该计划将支持MGH的RISE(项目#2)和BWH的Neu-Start，并在SPOTRIAS网络内收集和共享血浆和DNA样本。 SPOTRIAS血液和组织核心合作伙伴的目标是： 1.处理、维护和分发在MGH的RISE(项目2)中收集的血液样本。 2.支持BWH Neu-Start研究的血液采集和处理。 3.储存SPOTRIAS受试者的血液样本，以供日后合作研究之用。 4.收集遗传物质，提交NINDS储存库，以供今后在合作伙伴、SPOTRIAS网络、国际中风遗传学联合会(中风遗传学联合会)和更广泛的科学界内提出的遗传研究中使用。