Modeling of kinetic processes in biological systems

生物系统动力学过程建模

• 批准号: 7966736
• 负责人: Alexander Berezhkovskii
• 金额: $ 8.76万
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7966736
• 关键词: Biological Assay; Cell Communication; Cell Culture Techniques; Cells; Cereals; Complex; Dendritic Spines; Dependence; Development; Diffusion; Drosophila genus; Embryo; Entropy; Equation; Goals; Head and neck structure; Ion Channel; Ions; Kinetics; Modeling; Pathway interactions; Positioning Attribute; Process; Proteins; Radial; Reaction; Second Messenger Systems; Signal Transduction; System; Transmembrane Transport; Tube; Universities; Vertebral column; biological systems; insight; morphogens; particle; professor; protein folding; second messenger; theories

Channel-facilitated membrane transport. (i) We developed a general theory of fluctuations of ion current through a membrane channel due to partial blocking of the channel by translocating molecules. (ii) We developed a theory of transport of molecules through conical channels and showed that inter-particle interactions break the flux symmetry inherent in transport of non-interacting particles through such channels. Two-state protein folding. We developed a theory of two-state protein folding assuming that underlying dynamics is formulated in terms of rate equations on a network of coarse-grained discrete states of the protein. Our theory allows one to find folding and unfolding rates as well as most probable folding/unfolding pathways. Dynamics of morphogen gradients in the Drosophila Embrio. We developed a theory of signaling gradients in cascades of two-state reaction-diffusion systems that provides a new insight into the experimental observations made in Professor Shvartsman's Lab. at Princeton University. Transport in complex media with entropy traps and barriers. We developed a theory that explains anomalous dependence of the particle diffusivity on its radius for diffusion in tubes with dead ends. Diffusive escape from dendritic spines. We developed a theory that explains how the particle lifetime in a dendritic spine depends on geometric parameters of the spine, initial position of the particle, and its diffusivity in the spine neck and head.

凝胶促进膜转运。(i)我们发展了一个一般理论的波动离子电流通过膜通道由于部分阻塞的通道易位分子。(ii)我们开发了一个理论的分子通过圆锥形通道的运输，并表明，粒子间的相互作用打破了固有的通量对称性的非相互作用的粒子通过这样的通道的运输。 双态蛋白质折叠我们开发了一个理论的两个国家的蛋白质折叠假设的基础动力学制定的粗粒度离散状态的蛋白质网络上的速率方程。我们的理论允许人们找到折叠和展开速率以及最可能的折叠/展开途径。 果蝇胚胎中形态发生梯度的动力学。我们开发了一个理论的信号梯度级联的两个状态的反应扩散系统，提供了一个新的见解，在Shvartsman教授的实验室的实验观察。在普林斯顿大学。 具有熵陷阱和势垒的复杂介质中的输运。我们开发了一个理论，解释了异常依赖于其半径的颗粒扩散系数扩散管与死端。 从树突棘扩散逃逸。我们开发了一个理论，解释了如何在树突棘粒子的寿命取决于几何参数的脊柱，粒子的初始位置，其扩散率在脊柱颈部和头部。