Modeling of kinetic processes in biological systems

生物系统动力学过程建模

• 批准号: 8148484
• 负责人: Alexander Berezhkovskii
• 金额: $ 15.27万
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8148484
• 关键词: Kinetics; Modeling; Process; biological systems

Channel-facilitated membrane transport. (i) We applied our earlier developed theory to analyze blockage of Anthrax channel by multi-charged high-affinity toxin inhibitor. (ii) The effect of inter-particle interaction on particle transport through conical channels was studied both analytically and numerically. We showed that flux symmetry inherent in transport of non-interacting particles was broken by inter-particle repulsion. Our analytical predictions were in excellent agreement with numerical results obtained from Brownian dynamics simulations. Dynamics of morphogen gradients in the Drosophila Embrio. We developed a theory of local time that characterized formation of the morphogen gradient in a Drosophila Embrio. Our results show how the local time depends on the distance from the source of the morphogen and the distribution of the morphogen source intensity. Transport in complex media with entropy traps and barriers. Brownian dynamics simulations were used to study the dependence of the effective mobility and diffusion coefficient of a particle on the driving force in tubes of varying shape. Our results show that the dependences may be qualitatively different depending on the shape of the tube, i.e., the tube entropy potential.

通道促进的膜运输。(1)应用先前建立的理论分析了多电荷高亲和毒素抑制剂对炭疽通道的阻断作用。（ii）对粒子间相互作用对粒子通过锥形通道输运的影响进行了分析和数值研究。我们证明了非相互作用粒子输运中固有的通量对称性被粒子间排斥所打破。我们的分析预测与布朗动力学模拟得到的数值结果非常吻合。