权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Effect of Diet on Vascular Disease: Study of African American & Caucasian Women

饮食对血管疾病的影响：非裔美国人的研究

基本信息

批准号：
7967484
负责人：
Anne Sumner
金额：
$ 34.03万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7967484
关键词：
Accounting Affect African American Age American Award Basic Science Blood Blood Pressure Blood Vessels Blood flow Boxing Carbohydrates Cardiovascular Diseases Caucasians Caucasoid Race Characteristics Clinical Coagulation Process Data Analyses Development Diet Eligibility Determination Enrollment Evaluation Fatty acid glycerol esters Food Preferences Funding Guidelines Hepatic Hour Hypertriglyceridemia Individual Individual Differences Inflammation Inflammatory Insulin Resistance Investigation Lead Lipids Low Prevalence Measures Menopause Metabolic syndrome Outpatients Participant Peripheral Physiology Production Program Effectiveness Proteins Protocols documentation Public Health Schools Reliance Research Research Personnel Risk Sampling Screening procedure Stress Stroke Syndrome System Testing Triglycerides Ultrasonography United States United States National Institutes of Health Upper arm Vascular Diseases Visit Woman age effect apolipoprotein C-III bench to bedside cardiovascular risk factor design ethnic difference intravenous glucose tolerance test men mortality particle prevent response

项目摘要

For this study we will enroll 48 women (24 African American and 24 Caucasian women). To minimize the effect of age and menopause, we are enrolling women between the ages of 18 and 49 years. The study will involve several outpatient visits to the NIH Clinical Center. The first visit will be a screening to determine eligibility. At the second visit a test will be performed to measure insulin resistance. This test is called a frequently sampled intravenous glucose tolerance test. The third visit will be for the test meal. Before and at 2, 4 and 6 hours after the meal, blood will be drawn and vascular function measured. Vascular function is determined by taking blood pressure and then measuring blood flow in the arm with ultrasound. It is possible that individual differences in diet could affect the results of the vascular study on the day of the test meal. Therefore for 7 days prior to the test meal, the NIH Clinical Center will provide to each participant all their meals in the form of either trays or meals in a box. These meals will consist of the typical American diet and be 33% fat, 15% protein and 52% carbohydrate. In designing these meals, the dietician will take into account individual food preferences. Twenty-six women (13 African American and 13 Caucasian) have now completed the study. Enrollment and analyses of data already collected is underway.

在这项研究中，我们将招募 48 名女性（24 名非裔美国人和 24 名白人女性）。为了尽量减少年龄和更年期的影响，我们招募 18 岁至 49 岁之间的女性。该研究将涉及 NIH 临床中心的多次门诊就诊。第一次访问将进行筛选以确定资格。在第二次就诊时，将进行测试以测量胰岛素抵抗。该测试称为频繁采样静脉内葡萄糖耐量测试。第三次访问将是试餐。餐前以及餐后2、4和6小时，抽血并测量血管功能。通过测量血压然后用超声波测量手臂的血流量来确定血管功能。饮食的个体差异可能会影响测试餐当天血管研究的结果。因此，在测试餐前 7 天，NIH 临床中心将以托盘或盒装餐的形式向每位参与者提供所有餐食。这些膳食将由典型的美国饮食组成，其中包括 33% 的脂肪、15% 的蛋白质和 52% 的碳水化合物。在设计这些膳食时，营养师会考虑个人的食物偏好。 26 名女性（13 名非裔美国人和 13 名白人）现已完成这项研究。已收集数据的登记和分析正在进行中。