Obesity and Free Fatty Acid Flux

肥胖和游离脂肪酸通量

• 批准号: 8553508
• 负责人: Anne Sumner
• 金额: $ 4.66万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8553508
• 关键词: Adipose tissue; Affect; African American; American; Area; Blood Circulation; Clinic; Communities; County; Data; Development; Diabetes Mellitus; Diet; District of Columbia; Elements; Energy Metabolism; Enrollment; Ensure; Goals; Heart Diseases; Hospitals; Individual; Investigation; Lead; Length of Stay; Maryland; Measures; Metabolic; Minnesota; Nonesterified Fatty Acids; Obesity; Outpatients; Overweight; Participant; Prevalence; Process; Protocols documentation; Recruitment Activity; Research; Research Project Grants; Rest; Sex Characteristics; Site; United States National Institutes of Health; Weight; Weight maintenance regimen; Woman; design; ethnic difference; fatty acid metabolism; men; metropolitan; muscle form; programs; stable isotope

To determine if there are sex and ethnic differences in FFA flux and to ensure adequate enrollment of both African American and whites, this investigation is a collaborative effort between the National Institutes of Health (NIH) in Bethesda, Maryland and the Mayo Clinic in Olmsted County, Minnesota. The greater Washington, DC, metropolitan area, where NIH is located, has a large African-American community whereas over 90% of residents of Olmsted County are whites. Therefore, sex differences in FFA flux in African Americans will be mainly studied at the National Institutes of Health. Sex differences in FFA flux in whites will be mainly studied at the Mayo Clinic. The results of the two studies will be combined to determine if there are ethnic differences in FFA flux. To ensure results are attributable to ethnic differences (African American versus white) rather than site differences (NIH versus Mayo) some whites will be enrolled at NIH and some African Americans at Mayo. At NIH, 50 African-Americans (25M, 25W) and 14 whites (7M, 7W) will be enrolled. Equal numbers of normal weight, overweight and obese subjects will be recruited. As outpatients, participants will be placed on weight maintaining diets for two weeks and then admitted for a two-day hospital stay. On each in-hospital morning, resting energy expenditure will be measured and stable isotopes infused to measure FFA flux. Stable isotopes are naturally occurring forms of elements, which are safe and non-radioactive. At NIH 7 African-American men, 14 African-American women and 3 white women have completed the protocol and analyses are underway.

为了确定FFA流动是否存在性别和种族差异，并确保非洲裔美国人和白人都有足够的入学人数，这项调查是马里兰州贝塞斯达的国家卫生研究院(NIH)和明尼苏达州奥姆斯特县的梅奥诊所共同努力的结果。美国国立卫生研究院所在的大华盛顿特区大都市区有一个庞大的非裔美国人社区，而奥姆斯特德县90%以上的居民是白人。因此，非裔美国人FFA流量的性别差异将主要在美国国立卫生研究院进行研究。白人FFA流量的性别差异将主要在梅奥诊所进行研究。这两项研究的结果将结合起来确定FFA流量是否存在种族差异。为了确保结果归因于种族差异(非裔美国人对白人)，而不是地点差异(NIH对Mayo)，一些白人将被NIH录取，一些非裔美国人将被Mayo录取。 NIH将招收50名非裔美国人(2500万，25W)和14名白人(700万，7W)。将招募同等数量的正常体重、超重和肥胖受试者。作为门诊患者，参与者将被安排两周的减肥饮食，然后住院两天。在每个住院的早晨，将测量静息能量消耗，并输入稳定的同位素来测量FFA流量。稳定同位素是元素的自然存在形式，是安全和非放射性的。在NIH，7名非裔美国人男性、14名非洲裔美国女性和3名白人女性已经完成了方案，分析正在进行中。