Immune imprinting by nanoparticles and vaccines: new principles and translation into the clinic

纳米颗粒和疫苗的免疫印记：新原理及其临床转化

• 批准号: nhmrc : 1059409
• 负责人: Prof Magdalena Plebanski
• 金额: $ 42.08万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/immune-imprinting-nanoparticles-translation-clinic/454755
• 关键词: Immune; imprinting; nanoparticles; vaccines; new

Vaccines require adjuvants to be effective. Despite decades of research there is only one adjuvant approved for broad use in humans. Based on our prior findings I will engage new principles in nanotechnology, and deepen understanding of immune imprinting in various organs of the body including the lung, to develop 2nd generation broadly useful nanoadjuvants able to effectively treat cancer and malaria.

疫苗需要佐剂才能有效。尽管经过了几十年的研究，但只有一种佐剂被批准在人类身上广泛使用。基于我们之前的发现，我将在纳米技术中引入新的原理，并加深对包括肺部在内的人体不同器官中免疫印迹的理解，以开发能够有效治疗癌症和疟疾的第二代广泛有用的纳米佐剂。