Surface Enhanced Biocompatible Blood Oxygenators

描述（由申请人提供）：Compact Membrane Systems，Inc.提出开发具有增强的血液生物相容性的新型血液氧合器膜。这些将用于加强传统的心脏搭桥手术，最大限度地减少术后影响。此外，它们将为与体外膜氧合、急性呼吸窘迫综合征和人工肺相关的长期血液氧合提供关键要素。基于膜的血液氧合器成功地用于心肺旁路手术。许多项目正在评估用于人工肺和急性呼吸窘迫综合征的长期膜式血液氧合器。对于短期使用和长期使用，需要增强的血液相容性表面。目前用于增强血液相容性的两种涂层系统的实例是Avecor的Trillium和Medtronic的Carmeda。虽然这两种系统在增强血液相容性方面都取得了一些成功，但成功是有限的。这些系统倾向于减少气体（氧气）通量，并且最重要的是倾向于润湿。接触血液的材料和器械，如血液管路、透析膜和血液氧合器，要求组件材料具有血液相容性。这包括考虑血液的蛋白质和细胞系统。适当控制表面化学可增强生物相容性。Compact Membrane Systems，Inc. (CMS)在这方面有很强的专业知识CMS已经开发了一系列具有优异气体传输的无孔膜，其允许使用无孔膜来提供长期血液氧合所需的抗润湿性，同时保持高气体传输。这些膜现在将被用作增强生物相容性的构件。最终结果将是具有以下特征的血液氧合膜：与微孔聚丙烯相当的气体通量;无孔膜的抗润湿性;以及优异的血液生物相容性。这项工作的重点是通过控制表面化学来提高血液氧合器的生物相容性。所开发的技术应允许在血液透析膜上进行类似的开发，并将肝素聚合到膜表面。 公共卫生相关性：紧凑型膜系统公司提出开发具有增强的血液生物相容性的新型血液氧合器膜。这些将用于加强传统的心脏搭桥手术，最大限度地减少术后影响。此外，它们将为与体外膜氧合、急性呼吸窘迫综合征和人工肺相关的长期血液氧合提供关键要素。

DESCRIPTION (provided by applicant): Compact Membrane Systems, Inc. proposes to develop novel blood oxygenator membranes with enhanced blood biocompatibility. These will be used to enhance conventional cardio bypass surgery minimizing post operative effects. In addition, they will provide a key element for long term blood oxygenation associated with extracorporeal membrane oxygenation, acute respiratory distress syndrome, and artificial lungs. Membrane based blood oxygenators are successfully used for cardiopulmonary by-pass surgery. A number of programs are evaluating long-term membrane based blood oxygenators for artificial lungs and acute respiratory distress syndrome. For both short-term use and long-term use, there is a need for enhanced blood compatible surfaces. Examples of two coating systems that are presently used to enhance blood compatibility are Avecor's Trillium and Medtronic's Carmeda. While both of these systems have some success in enhancing blood compatibility, the success is limited. These systems tend to reduce gas (oxygen) flux and most importantly are prone to wetting out. Materials and devices that contact blood, such as blood tubing, dialysis membranes and blood oxygenators, require blood compatibility of the component materials. This includes consideration of the protein and cellular systems of the blood. Proper control of surface chemistry can enhance biocompatibility. Compact Membrane Systems, Inc. (CMS) has significant expertise in this area. A family of non-porous membranes with excellent gas transport that allows the use of a non-porous membrane to provide the needed wet out resistance for long term blood oxygenation while maintaining high gas transport has been developed by CMS. These membranes will now be used as the building block for enhancing biocompatibility. The net result will be a blood oxygenation membrane with the following features: gas flux comparable to micro porous polypropylene; wet out resistance of a non-porous membrane; and, excellent blood biocompatibility. This work will focus on enhancing the biocompatibility of blood oxygenators by controlling surface chemistry. The technology developed should allow similar developments on hemodialysis membranes and also working with polymerization of heparin to the surface of membranes. PUBLIC HEALTH RELEVANCE: Compact Membrane Systems, Inc. proposes to develop novel blood oxygenator membranes with enhanced blood biocompatibility. These will be used to enhance conventional cardio bypass surgery minimizing post operative effects. In addition, they will provide a key element for long term blood oxygenation associated with extracorporeal membrane oxygenation, acute respiratory distress syndrome, and artificial lungs.