Mid-infrared Laser Blood Glucose Monitor

中红外激光血糖仪

• 批准号: 7908390
• 负责人: Igor E Trofimov
• 金额: $ 10.49万
• 依托单位: PTAC, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7908390
• 关键词: Accounting; Blood Glucose; Caring; Cattle; Centers for Disease Control and Prevention (U.S.); Chemicals; Cholesterol; Clinical; Clinical Trials; Computer software; Data; Data Analyses; Detection; Developing Countries; Development; Devices; Diabetes Mellitus; Diagnosis; Diagnostic Procedure; Dialysis procedure; Diffuse; Disease; Electronics; Environment; Evaluation; Exhibits; Forearm; Future; Generations; Glucose; Goals; Hand; Health; Hospitals; In Vitro; Lasers; Light; Measurement; Miniaturization; Monitor; Noise; Optics; Outcome; Output; Patients; Performance; Phase; Physiological; Population; Relative (related person); Reporting; Resolution; Scanning; Sensitivity and Specificity; Serum; Signal Transduction; Small Business Technology Transfer Research; Solutions; Source; Specificity; Specimen; Spectrophotometry; Spectrum Analysis; Structure; System; Techniques; Technology; Testing; Urea; Water; absorption; base; cost; design; diabetic; glucose monitor; human subject; improved; in vivo; instrument; migration; non-invasive monitor; novel; programs; prototype; public health relevance; research clinical testing; transmission process

DESCRIPTION (provided by applicant): The proposed STTR Phase I program will develop a novel non-invasive blood glucose monitor. Non-invasive blood glucose monitors that utilize conventional spectrometers and thermal light sources suffer from insufficient signal-to-noise ratio for the stable prediction of glucose concentration. The proposed laser-based system exhibits superior signal-to-noise measurements of glucose, and therefore better sensitivity and specificity. These in turn will provide a better account for physiological and phenotypic variables. The proposed technology has the significant advantage over other approaches of being based upon an inherently miniaturizable, power-efficient, and mechanically stable technology that will permit the development of a compact robust system. During Phase II of this program, the clinical prototypes of non-invasive monitor will be constructed and tested in-vivo on human subjects. PUBLIC HEALTH RELEVANCE: Diabetes mellitus is a large and growing problem throughout the world's developed and developing nations. According to the statistical data collected by the Centers for Disease Control and Prevention (CDC) in 2007, a total of 23.6 million people in USA or 7.8 percent of the population have diabetes. It is estimated that only 17.9 million people are diagnosed with diabetes mellitus while 5.7 million people remain undiagnosed mostly due to the lack of easy diagnostic techniques. The goal in this proposal is to develop a compact non-invasive blood glucose monitor for clinical environment. The utility of the proposed technology goes beyond the proposed application in diabetes care. It has potential in the detection of cholesterol, monitoring urea during dialysis, and many other applications in health and disease.

描述（由申请人提供）：拟议的STTR I期项目将开发一种新型无创血糖监测仪。利用常规光谱仪和热光源的非侵入式血糖监测器遭受用于稳定预测葡萄糖浓度的信噪比不足。所提出的基于激光的系统表现出葡萄糖的上级信噪比测量，因此具有更好的灵敏度和特异性。这些反过来将提供一个更好的帐户的生理和表型变量。所提出的技术具有显着的优势，比其他方法的基础上，一个固有的可扩展的，功率效率高，机械稳定的技术，将允许开发一个紧凑的强大的系统。在该计划的第二阶段，将构建无创监测器的临床原型并在人体受试者身上进行体内测试。 公共卫生相关性：糖尿病是世界上发达国家和发展中国家面临的一个日益严重的问题。根据美国疾病控制与预防中心（CDC）2007年收集的统计数据，美国共有2360万人患有糖尿病，占总人口的7.8%。据估计，只有1790万人被诊断患有糖尿病，而570万人仍然未被诊断，主要是由于缺乏简单的诊断技术。本提案的目标是开发一种适用于临床环境的紧凑型无创血糖监测仪。所提出的技术的实用性超出了糖尿病护理中的拟议应用。它在检测胆固醇、监测透析期间的尿素以及许多其他健康和疾病应用方面具有潜力。