Non-invasive blood glucose monitor

无创血糖监测仪

• 批准号: 6834956
• 负责人: Igor E Trofimov
• 金额: $ 9.99万
• 依托单位: PTAC, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6834956
• 关键词: biochemistry; blood glucose; fiber optics; hospitals; infrared spectrometry; lasers; patient monitoring device; semiconduction; technology /technique development

DESCRIPTION (provided by applicant): The proposed program will develop a novel near-infrared laser based spectrophotometer suitable for transcutaneous determination of blood glucose. Non-invasive blood glucose monitors that utilize conventional spectrometers and thermal light sources suffer from insufficient signal-to-noise ratio for the stable prediction of glucose concentration. The laser-based system we propose to develop and test is expected to exhibit superior signal-to-noise measurements of glucose, and therefore better sensitivity and specificity. These in turn will provide a better account for physiological and phenotypic variables. The proposed technology has the significant advantage over other approaches of being based upon an inherently miniaturizable, power-efficient, and mechanically stable technology that will permit the development of a compact robust system. This technology promises to produce a fundamental improvement in the frequency with which diabetic patients monitor their blood glucose. It will have a major impact on the public health issues arising from diabetes. Phase I of this project will determine the feasibility of the proposed approach by in-vitro measurements of clinical samples of whole blood. During Phase II of this project a prototype of a hand-held in-vivo monitor based upon the system engineered in Phase I will be constructed, and clinical trials will be conducted. Total diabetes glucose self-monitoring devices market for the U.S. alone was valued at $1.2 billion. There are number of industries that this technology could provide benefits. Besides obvious applications in medical devices for glucose measurements, and monitoring other metabolites in human body, it can be used in food and pharmaceutical industries, as well as for environmental monitoring and industrial safety.

描述（由申请人提供）： 本计画将发展一种适用于经皮血糖测定之新型近红外雷射分光光度计。利用常规光谱仪和热光源的非侵入式血糖监测器遭受用于稳定预测葡萄糖浓度的信噪比不足。我们建议开发和测试的基于激光的系统有望表现出葡萄糖的上级信噪比测量，因此具有更好的灵敏度和特异性。这些反过来将提供一个更好的帐户的生理和表型变量。所提出的技术具有显着的优势，比其他方法的基础上，一个固有的可扩展的，功率效率高，机械稳定的技术，将允许开发一个紧凑的强大的系统。这项技术有望从根本上提高糖尿病患者监测血糖的频率。它将对糖尿病引起的公共卫生问题产生重大影响。 该项目的第一阶段将通过对全血临床样本的体外测量来确定拟议方法的可行性。在该项目的第二阶段，将根据第一阶段设计的系统构建手持式体内监测器的原型，并进行临床试验。 仅美国的糖尿病血糖自我监测设备市场就价值12亿美元。 有许多行业可以利用这项技术。除了在葡萄糖测量和监测人体内其他代谢物的医疗设备中的明显应用外，它还可用于食品和制药工业，以及环境监测和工业安全。