Immune regulation of colitis and associated cancer

结肠炎和相关癌症的免疫调节

• 批准号: nhmrc : GNT1099262
• 负责人: A/Pr Seth Masters
• 金额: $ 64.7万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/immune-regulation-colitis-associated-cancer/1346045
• 关键词: Immune; regulation; colitis; associated; cancer

Inflammatory bowel disease is a debilitating condition that can significantly increase the likelihood of developing colon cancer. There are many different cellular pathways that lead to this inflammation, but we have uncovered a key signal that can prevent it from occurring. Specifically, we have identified how this signal increases a new type of suppressive cell that fights inflammation in the colon and can also stop this leading cancer.

炎症性肠病是一种使人衰弱的疾病，可显著增加患结肠癌的可能性。有许多不同的细胞通路导致这种炎症，但我们已经发现了一个关键信号，可以防止它发生。具体来说，我们已经确定了这种信号如何增加一种新型的抑制细胞，这种细胞可以对抗结肠炎症，也可以阻止这种主要的癌症。