PSTPIP1, actin and the Pyrin inflammasome

许多白血球具有天生的感知感染的能力，并引发炎症来对抗入侵的微生物。这些先天免疫细胞使用特定的受体来感知病原体，我们现在已经确定了一种新的途径，可以导致其中之一的激活，称为比林。基因突变可以激活这一途径，我们的项目将确定这一途径的分子基础，以及如何将其作为治疗炎症性疾病的靶点。

Many white blood cells have an innate ability to sense infection, and trigger inflammation to fight invading microbes. These innate immune cells use particular receptors to sense pathogens and we have now identified a new pathway that leads to the activation of one of these, known as Pyrin. Genetic mutations can activate this pathway, and our project will determine the molecular basis for this, and how it can be targeted to treat inflammatory disease.