Interleukin-1β biology: mechanisms of regulation, activation and secretion

Interleukin-1β 生物学：调节、激活和分泌机制

• 批准号: nhmrc : GNT1101405
• 负责人: A/Pr Seth Masters
• 金额: $ 64.2万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interleukin-1-biology-activation-secretion/1346160
• 关键词: Interleukin; biology; mechanisms; regulation; activation

The protein called intelreukin-1 (IL-1) is required to fight off invading pathogens but more recently has been implicated as contributing to diverse diseases characterised by excessive inflammation, such as arthritis, gout, atherosclerosis and even cancer. This project aims to understand how IL-1 is made within cells and then activated to cause inflammation, which will enable these processes to be therapeutically targeted.

这种被称为白细胞介素-1（IL-1）的蛋白质是抵御入侵病原体所必需的，但最近被认为是导致以过度炎症为特征的多种疾病的原因，如关节炎、痛风、动脉粥样硬化甚至癌症。该项目旨在了解IL-1是如何在细胞内产生，然后被激活引起炎症的，这将使这些过程成为治疗靶点。