The inflammasome and autoinflammatory disease

免疫系统有两个分支，一个是学习和适应，这可能导致自身免疫性疾病，另一个是直接和先天的，可能导致自身炎症性疾病。这项提议继续了我们在罕见遗传性自身炎性疾病特征方面的工作，并将这些研究推广到更常见的慢性炎性疾病。这将改善目前的诊断和治疗，并阐明未来可以在临床上靶向的药物靶点。

There are two arms to the immune system, one that learns and adapts, which can cause autoimmune disease, and another that is immediate and innate, and can cause autoinflammatory disease. This proposal continues our work in the characterization of rare genetic autoinflammatory disesaes and extrapolates these studies to more common chronic inflammatory diseases. This stands to improve current diagnosis and treatment, and elucidate future drug targets that could be targeted clinically.