The inflammasome and autoinflammatory disease

炎症小体和自身炎症性疾病

• 批准号: nhmrc : GNT1122338
• 负责人: A/Pr Seth Masters
• 金额: $ 77.26万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inflammasome-autoinflammatory-disease/1347267
• 关键词: inflammasome; autoinflammatory; disease

There are two arms to the immune system, one that learns and adapts, which can cause autoimmune disease, and another that is immediate and innate, and can cause autoinflammatory disease. This proposal continues our work in the characterization of rare genetic autoinflammatory disesaes and extrapolates these studies to more common chronic inflammatory diseases. This stands to improve current diagnosis and treatment, and elucidate future drug targets that could be targeted clinically.

免疫系统有两只手臂，一只是学习和适应的，可能导致自身免疫性疾病，另一只是直接的、先天的，可能导致自身炎症性疾病。该提案继续了我们在罕见遗传性自身炎症性疾病表征方面的工作，并将这些研究外推到更常见的慢性炎症性疾病。这将改善当前的诊断和治疗，并阐明未来可用于临床的药物靶点。