Acuson Sequoia C512 Echocardiography System

Acuson Sequoia C512 超声心动图系统

• 批准号: 7791820
• 负责人: Sandrine V Pierre
• 金额: $ 10.05万
• 依托单位: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7791820
• 关键词: Advisory Committees; Animal Experimentation; Animals; Applications Grants; Area; Binding; Blood Pressure; Calpain; Cardiac; Cardiac Myocytes; Cardiomyopathies; Cardiovascular Diseases; Cardiovascular system; Cell membrane; Complex; Contract Services; Data; Development; Diabetes Mellitus; Digitalis preparation; Echocardiography; Equipment; Funding; Genetic Determinism; Grant; Health Sciences; Heart; Heart Hypertrophy; Heart failure; Hypertension; Hypertrophy; Image; Insulin Resistance; Laboratories; Left Ventricular Hypertrophy; Mediating; Medical; Metabolic syndrome; Minor; Myocardial Ischemia; Na(+)-K(+)-Exchanging ATPase; Performance; Pharmacology; Phenotype; Physiological; Physiology; Process; Program Research Project Grants; Research; Research Personnel; Resource Sharing; Role; Schedule; Sequoia; Signal Transduction; Solutions; Supervision; System; TRPC3 ion channel; Training; Ultrasonography; Universities; Work; atherogenesis; cost; diabetic cardiomyopathy; fatty acid metabolism; instrument; instrumentation; meetings; public health relevance; receptor; repaired; response; tool

DESCRIPTION (provided by applicant): This is a shared instrumentation proposal to acquire an ACUSON SequoiaTM C512 cardiac ultrasound imaging system, manufactured by Siemens Medical Solutions USA, Inc. Echocardiography is widely accepted as a valuable research tool for studying a broad range of cardiovascular disease processes in small animals, including ischemic heart disease, heart failure, cardiac hypertrophy and remodeling, hypertension and diabetic cardiomyopathy. Although the University of Toledo has nationally recognized NIH-funded investigators working in many of these areas, the university currently does not have adequate access to an ultrasound machine that is capable of providing in-depth cardiac assessment of small research animals. Consequently, investigators have had to seek alternative, invasive approaches to assessing cardiac function and remodeling, leading to higher costs, increased animal use and lower efficiency. By meeting a critical need for small animal echocardiography, the acquisition of the ACUSON Sequoia system will greatly facilitate progress on active NIH-sponsored R01 projects as well as a Program Project Grant (2P01) directed by the major users. In addition, access to this shared equipment will be extended to minor users and new users who have active grant support or are seeking to develop preliminary data for new grant applications. The equipment will be located in the Cardiovascular Phenotyping Core Laboratory of the Department of Physiology and Pharmacology on the University of Toledo's Health Science Campus, and space within the lab will be allocated to facilitate studies for all users. The day-to-day scheduling, training, and technical support for the instrument will be handled under the auspices of the Core Laboratory, with administrative supervision from the PI and an Internal Advisory Committee. Institutional support for the instrument will come in the form of space allocation and a 50% subsidy for the annual service contract. Ongoing projects that will benefit from the Sequoia system include: 1) Studies aimed at exploring mechanisms of digitalis mediated cardiac myocyte hypertrophy; 2) Studies of the molecular interactions that constitute the formation of the Na/K-ATPase/Src receptor complex, and to evaluate the functionality and physiologic response of this newly discovered receptor in digitalis- activated signal transduction in the heart; 3) Studies to identify genetic determinants of blood pressure and their effects on cardiac function and remodeling; and 4) Studies aimed at identifying the mechanisms by which insulin resistance leads to metabolic syndrome and its associated cardiovascular effects. Several new projects focused on cardiac fatty acid metabolism, uremic cardiomyopathy, the role of calpains in the repair of the damaged plasma membranes of damaged cardiomyoctes, and the role of TRPC3 channels in atherogenesis and the development of left ventricular hypertrophy will also benefit from the availability of the requested imaging system. By accelerating progress on these diverse projects, this shared instrumentation will have a major positive impact on health-related research at the University of Toledo. PUBLIC HEALTH RELEVANCE: We are requesting funds to acquire an ACUSON SequoiaTM C512 cardiac ultrasound system, which is a well established instrument with an excellent performance record and widespread acceptance of echocardiographic data generated from large and small research animals alike. This instrument is not currently available at this university. It will be operated as a shared resource to accelerate the cardiovascular-related research of numerous investigators including three major users who are engaged in NIH-sponsored projects focused on cardiac hypertrophy, hypertension and diabetes.

描述（由申请人提供）：这是一份共享仪器提案，旨在获得由Siemens Medical Solutions USA，Inc.制造的ACUSON SequoiaTM C512心脏超声成像系统。超声心动图被广泛认为是研究小动物广泛心血管疾病过程的有价值的研究工具，包括缺血性心脏病、心力衰竭、心脏肥大和重塑、高血压和糖尿病心肌病。虽然托莱多大学拥有国家认可的NIH资助的研究人员在这些领域中的许多领域工作，但该大学目前没有足够的超声波机器能够对小型研究动物进行深入的心脏评估。因此，研究人员不得不寻求替代的侵入性方法来评估心脏功能和重塑，导致成本更高，动物使用增加和效率降低。通过满足对小动物超声心动图的迫切需求，收购ACUSON Sequoia系统将大大促进NIH赞助的R 01项目以及主要用户指导的计划项目赠款（2 P01）的进展。此外，将扩大使用这一共用设备的范围，使那些获得积极赠款支助或正在设法为新的赠款申请编制初步数据的小用户和新用户也能使用。该设备将位于托莱多大学健康科学校区生理学和药理学系的心血管表型核心实验室，实验室内的空间将分配给所有用户以方便研究。仪器的日常安排、培训和技术支持将在核心实验室的主持下进行，并由PI和内部咨询委员会进行行政监督。对该仪器的机构支持将以空间分配和年度服务合同50%补贴的形式提供。正在进行的项目将受益于红杉系统包括：1）旨在探索洋地黄介导的心肌细胞肥大机制的研究; 2）研究构成Na/K-ATP酶/Src受体复合物形成的分子相互作用，并评估这种新发现的受体在洋地黄激活的心脏信号转导中的功能和生理反应; 3）确定血压的遗传决定因素及其对心脏功能和重塑的影响的研究;以及4）旨在确定胰岛素抵抗导致代谢综合征及其相关心血管效应的机制的研究。几个新的项目集中在心脏脂肪酸代谢，尿毒症心肌病，钙蛋白酶在受损心肌细胞受损质膜修复中的作用，以及TRPC 3通道在动脉粥样硬化形成和左心室肥大发展中的作用，也将受益于所需成像系统的可用性。通过加快这些不同项目的进展，这种共享的仪器将对托莱多大学的健康相关研究产生重大的积极影响。 公共卫生相关性：我们正在申请资金购买ACUSON SequoiaTM C512心脏超声系统，该系统是一种成熟的仪器，具有出色的性能记录，并广泛接受大型和小型研究动物产生的超声心动图数据。这所大学目前没有这种仪器。它将作为共享资源运行，以加速众多研究人员的心血管相关研究，其中包括三个主要用户，他们参与了NIH赞助的心脏肥大，高血压和糖尿病项目。